We evaluated the toxicity of graphite nanoplatelets (GNPs) in the model organism Caenorhabditis elegans. The GNPs resulted nontoxic by measuring longevity as well as reproductive capability end points. An imaging technique based on Fourier transform infrared spectroscopy (FT-IR) mapping was also developed to analyze the GNPs spatial distribution inside the nematodes. Conflicting reports on the in vitro antimicrobial properties of graphene-based nanomaterials prompted us to challenge the host-pathogen system C. elegans-Pseudomonas aeruginosa to assess these findings through an in vivo model. © 2012 American Chemical Society.
Graphite nanoplatelets and Caenorhabditis elegans: Insights from an in vivo model / Zanni, Elena; DE BELLIS, Giovanni; Bracciale, MARIA PAOLA; Broggi, Alessandra; Santarelli, Maria Laura; Sarto, Maria Sabrina; Palleschi, Claudio; Uccelletti, Daniela. - In: NANO LETTERS. - ISSN 1530-6984. - ELETTRONICO. - 12:6(2012), pp. 2740-2744. [10.1021/nl204388p]
Graphite nanoplatelets and Caenorhabditis elegans: Insights from an in vivo model
ZANNI, ELENA;DE BELLIS, GIOVANNI;BRACCIALE, MARIA PAOLA;BROGGI, ALESSANDRA;SANTARELLI, Maria Laura;SARTO, Maria Sabrina;PALLESCHI, Claudio;UCCELLETTI, Daniela
2012
Abstract
We evaluated the toxicity of graphite nanoplatelets (GNPs) in the model organism Caenorhabditis elegans. The GNPs resulted nontoxic by measuring longevity as well as reproductive capability end points. An imaging technique based on Fourier transform infrared spectroscopy (FT-IR) mapping was also developed to analyze the GNPs spatial distribution inside the nematodes. Conflicting reports on the in vitro antimicrobial properties of graphene-based nanomaterials prompted us to challenge the host-pathogen system C. elegans-Pseudomonas aeruginosa to assess these findings through an in vivo model. © 2012 American Chemical Society.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
