Cell-mediated cytotoxic response in vitro to a Moloney strain of murine leukemia virus-induced tumor (LSTRA) altered by 5-(3,3-dimethyl-1- triazeno)imidazole-4-carboxamide (DTIC) was investigated with the use of mixed-leukocyte tumor cell cultures (MLTC). As assessed by means of a short-term 51Cr-release assay, minimal or no cytolytic activity was generated in primary MLTC. In contrast, high specific cytotoxic response against the altered tumor was obtained in secondary MLTC. Partial cross-reactivity was found between the LSTRA and LSTRA/DTIC tumor lines.
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|Titolo:||Secondary cytotoxic response in vitro against Moloney lymphoma cells antigenically altered by drug treatment in vivo|
|Data di pubblicazione:||1978|
|Appartiene alla tipologia:||01a Articolo in rivista|