Treatment of older mice with pyran copolymer, a known interferon-inducer, was found to result in a rapid boosting of cell-mediated cytolytic activity against YAC-1 tumor target cells. The effector cells were characterized as being non-adherent and were presumed to be natural killer (NK) cells. Augmentation occurred in various lymphoid organs and was detectable 2-3 days after drug treatment. Differences in the levels of boosted activity among the lymphoid organs resulted when the route of administration was varied. The degree of augmentation was largely independent of the dose of pyran, but did vary among different strains of mice. Augmentation, moreover, was followed by a rapid decline by 5-7 days.

Augmentation of natural killer activity by pyran copolymer in mice / Santoni, Angela; Puccetti, P; Riccardi, C; Herberman, Rb; Bonmassar, E.. - In: INTERNATIONAL JOURNAL OF CANCER. - ISSN 0020-7136. - STAMPA. - 24:(1979), pp. 656-661.

Augmentation of natural killer activity by pyran copolymer in mice.

SANTONI, Angela;
1979

Abstract

Treatment of older mice with pyran copolymer, a known interferon-inducer, was found to result in a rapid boosting of cell-mediated cytolytic activity against YAC-1 tumor target cells. The effector cells were characterized as being non-adherent and were presumed to be natural killer (NK) cells. Augmentation occurred in various lymphoid organs and was detectable 2-3 days after drug treatment. Differences in the levels of boosted activity among the lymphoid organs resulted when the route of administration was varied. The degree of augmentation was largely independent of the dose of pyran, but did vary among different strains of mice. Augmentation, moreover, was followed by a rapid decline by 5-7 days.
1979
01 Pubblicazione su rivista::01a Articolo in rivista
Augmentation of natural killer activity by pyran copolymer in mice / Santoni, Angela; Puccetti, P; Riccardi, C; Herberman, Rb; Bonmassar, E.. - In: INTERNATIONAL JOURNAL OF CANCER. - ISSN 0020-7136. - STAMPA. - 24:(1979), pp. 656-661.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/450722
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