INTERLEUKIN-6 PRODUCTION BY HUMAN HEPATOMA LINES IS RELATED TO A LOW DEGREE OF CELL-DIFFERENTIATION

Paroli, Marino; Carloni, G.; Alfani, E.; De Petrillo, G.; Barnaba, Vincenzo

doi:10.1016/s0923-2516(06)80048-8

In this study, we showed by Northern blot analysis and bioassays that scarcely differentiated human hepatoma cell line HA22T/VGH constitutively produces interleukin-6 (IL6). This cytokine was produced neither by moderately differentiated Li7A nor by well-differentiated HepG2 human hepatoma cell lines. The finding that transcripts for IL6 were not present in 2.2.15 cells, a HepG2-derived clone transfected with the intracellular replicative form of hepatitis B virus (HBV) DNA, suggests that production of this cytokine is not affected by HBV-encoded gene products, but is more likely related to the dedifferentiated state of hepatoma cells.

INTERLEUKIN-6 PRODUCTION BY HUMAN HEPATOMA LINES IS RELATED TO A LOW DEGREE OF CELL-DIFFERENTIATION / Paroli, Marino; G., Carloni; E., Alfani; G., De Petrillo; Barnaba, Vincenzo. - In: RESEARCH IN VIROLOGY. - ISSN 0923-2516. - 144:4(1993), pp. 323-326. [10.1016/s0923-2516(06)80048-8]

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Titolo:	INTERLEUKIN-6 PRODUCTION BY HUMAN HEPATOMA LINES IS RELATED TO A LOW DEGREE OF CELL-DIFFERENTIATION
Autori:	PAROLI, Marino G. Carloni E. Alfani G. De Petrillo BARNABA, Vincenzo mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1993
Rivista:	RESEARCH IN VIROLOGY
Citazione:	INTERLEUKIN-6 PRODUCTION BY HUMAN HEPATOMA LINES IS RELATED TO A LOW DEGREE OF CELL-DIFFERENTIATION / Paroli, Marino; G., Carloni; E., Alfani; G., De Petrillo; Barnaba, Vincenzo. - In: RESEARCH IN VIROLOGY. - ISSN 0923-2516. - 144:4(1993), pp. 323-326. [10.1016/s0923-2516(06)80048-8]
Handle:	http://hdl.handle.net/11573/450527
Appartiene alla tipologia:	01a Articolo in rivista

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