Bicarbonate excretion in bile is a major function of the biliary epithelium. it is driven by the apically located Cl(-)/HCO(3)(-) exchanger which is functionally coupled with a cAMP-dependent Cl(-) channel (CFTR). A number of hormones and/or neuropeptides with different mechanisms and at different intracellular levels regulate, in concert, the processes underlying bicarbonate excretion in the biliary epithelium. Secretin induces a bicarbonate rich choleresis by stimulating the activity of the Cl-/HCO(3)(-) exchanger by cAMP and protein kinase A mediated phosphorylation of CFTR regulatory domain. Protein phosphatase 1/2A are involved in the run-down of secretory stimulus after secretin removal. Acetylchorine potentiates secretin-choleresis by inducing a Ca(++)-calcineurin mediated "sensitization" of adenyl cyclase to secretin. Bombesin and vasoactive intestinal peptide also enhance the Cl(-)/HCO(3)(-) exchanger activity, but the intracellular signal transduction pathway has not yet been defined. Somatostatin and gastrin inhibit basal and/or secretin-stimulated bicarbonate excretion by downregulating the secretin receptor and decreasing cAMP intracellular levels induced by secretin.

Hormonal regulation of bicarbonate secretion in the biliary epithelium / Alvaro, Domenico; A., Gigliozzi; F., Fraioli; R., Romeo; E., Papa; M., Delle Monache; L., Capocaccia. - In: THE YALE JOURNAL OF BIOLOGY AND MEDICINE. - ISSN 0044-0086. - 70:4(1997), pp. 417-426. (Intervento presentato al convegno Recent Advances in Liver Research - Symposium in Honor of Professor James L Boyer tenutosi a NEW HAVEN, CT nel MAY 08-09, 1997).

Hormonal regulation of bicarbonate secretion in the biliary epithelium

ALVARO, Domenico;
1997

Abstract

Bicarbonate excretion in bile is a major function of the biliary epithelium. it is driven by the apically located Cl(-)/HCO(3)(-) exchanger which is functionally coupled with a cAMP-dependent Cl(-) channel (CFTR). A number of hormones and/or neuropeptides with different mechanisms and at different intracellular levels regulate, in concert, the processes underlying bicarbonate excretion in the biliary epithelium. Secretin induces a bicarbonate rich choleresis by stimulating the activity of the Cl-/HCO(3)(-) exchanger by cAMP and protein kinase A mediated phosphorylation of CFTR regulatory domain. Protein phosphatase 1/2A are involved in the run-down of secretory stimulus after secretin removal. Acetylchorine potentiates secretin-choleresis by inducing a Ca(++)-calcineurin mediated "sensitization" of adenyl cyclase to secretin. Bombesin and vasoactive intestinal peptide also enhance the Cl(-)/HCO(3)(-) exchanger activity, but the intracellular signal transduction pathway has not yet been defined. Somatostatin and gastrin inhibit basal and/or secretin-stimulated bicarbonate excretion by downregulating the secretin receptor and decreasing cAMP intracellular levels induced by secretin.
1997
01 Pubblicazione su rivista::01a Articolo in rivista
Hormonal regulation of bicarbonate secretion in the biliary epithelium / Alvaro, Domenico; A., Gigliozzi; F., Fraioli; R., Romeo; E., Papa; M., Delle Monache; L., Capocaccia. - In: THE YALE JOURNAL OF BIOLOGY AND MEDICINE. - ISSN 0044-0086. - 70:4(1997), pp. 417-426. (Intervento presentato al convegno Recent Advances in Liver Research - Symposium in Honor of Professor James L Boyer tenutosi a NEW HAVEN, CT nel MAY 08-09, 1997).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/450521
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