Objectives: We analyze our experience on BPH through 20 years of histopathological examinations performed by the same pathologist. Methods: We retrospectively reviewed all histopathological examinations performed from January 1979 to December 1998 in patients undergoing surgery in our urological clinic who were diagnosed with BPH. We limited our evaluation to the following variables in each BPH case analyzed: inflammatory aspects associated with BPH, presence of focal acinar atrophy, atypical adenomatous hyperplasia (AAH), prostatic intraepithelial neoplasia (PIN), incidental prostate carcinoma (IC). These histological variables were analyzed according to some clinical parameters such as age, prostate volume and serum PSA. Results: The study population was comprised of 3942 cases with histological diagnosis of BPH. The mean patient age was 68.85 +/- 7.67 years. In particular, inflammatory aspects were associated with BPH in a high percentage of cases (43.1% = 1700 cases), predominantly as chronic inflammation. Observation of focal acinar atrophy significantly increased according to patient decade of age (p = 0.027). There was a significant trend to increase with age decades (p = 0.036) for high grade PIN. A significant difference was found in IC (T1a, T1b) distribution in the different decades of age and especially in regards to both T1a and T1b tumors, there was a trend to increase with patient age (p = 0.020 and p = 0.025, respectively). On the contrary, the distribution of inflammatory aspects (p < 0.001) and AAH (p = 0.003) significantly varied according to prostate volume, and particularly in regards to chronic inflammation, there was a trend to increase depending on the prostate volume (p = 0.002). Only the presence of T1b tumor but not of the other histological parameters associated to BPH, was able to significantly influence serum PSA. Conclusion: In our analysis different histological variables associated to BPH are differently influenced by the age of patients and prostate volume, and they differently influence serum PSA levels. (C) 2002 Elsevier Science B.V. All rights reserved.
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|Titolo:||Distribution of inflammation, pre-malignant lesions, incidental carcinoma in histologically confirmed benign prostatic hyperplasia: A retrospective analysis|
|Data di pubblicazione:||2003|
|Appartiene alla tipologia:||01a Articolo in rivista|