Leaves of Olea europaea, cultivar Nocellara del Belice, were examined with respect to the medium-polar fraction, obtained by an ethyl acetate extraction of the whole extract. In the medium polar fraction, we isolated the two hydroxy-phenyl-ethyl alcohols (hydroxyl-tyrosol and tyrosol) that are the main component of olives. In addition, we isolated a flavonoidic compound, aromadendrine, a dihydroflavonol yet known but quite rare in nature. It is the first time that aromadendrine is isolated in O. europaea and we studied the aromadendrine biological activity. In particular, the ability of aromadendrine to reduce the inflammation induced in normal keratinocytes using an invitro cell model was evaluated. The results of the present research indicate aromadendrine as a novel component in O. europaea with effective activity against skin inflammation.

Aromadendrine, a new component of the flavonoid pattern of Olea europaea L. and its anti-inflammatory activity / Venditti, Alessandro; Serrilli, ANNA MARIA; Luisa, Rizza; Giuseppina, Frasca; Venera, Cardile; Francesco Paolo, Bonina; Bianco, Armandodoriano. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - STAMPA. - 27:4-5(2013), pp. 340-349. [10.1080/14786419.2012.693924]

Aromadendrine, a new component of the flavonoid pattern of Olea europaea L. and its anti-inflammatory activity

VENDITTI, ALESSANDRO;SERRILLI, ANNA MARIA;BIANCO, Armandodoriano
2013

Abstract

Leaves of Olea europaea, cultivar Nocellara del Belice, were examined with respect to the medium-polar fraction, obtained by an ethyl acetate extraction of the whole extract. In the medium polar fraction, we isolated the two hydroxy-phenyl-ethyl alcohols (hydroxyl-tyrosol and tyrosol) that are the main component of olives. In addition, we isolated a flavonoidic compound, aromadendrine, a dihydroflavonol yet known but quite rare in nature. It is the first time that aromadendrine is isolated in O. europaea and we studied the aromadendrine biological activity. In particular, the ability of aromadendrine to reduce the inflammation induced in normal keratinocytes using an invitro cell model was evaluated. The results of the present research indicate aromadendrine as a novel component in O. europaea with effective activity against skin inflammation.
aromadendrine; dihydroflavonol; flavonoids; olea europaea
01 Pubblicazione su rivista::01a Articolo in rivista
Aromadendrine, a new component of the flavonoid pattern of Olea europaea L. and its anti-inflammatory activity / Venditti, Alessandro; Serrilli, ANNA MARIA; Luisa, Rizza; Giuseppina, Frasca; Venera, Cardile; Francesco Paolo, Bonina; Bianco, Armandodoriano. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - STAMPA. - 27:4-5(2013), pp. 340-349. [10.1080/14786419.2012.693924]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/448592
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