Nineteen obese female subjects with body mass index ranging between 30 and 40 were included in a double-blind crossover study aimed at evaluating the effects of oral 5-hydroxytryptophan administration on feeding behavior, mood state and weight loss. Either 5-hydroxytryptophan (8 mg/kg/day) or placebo was administered for five weeks during which patients were not prescribed any dietary restrictions. Feeding behavior was investigated by means of a questionnaire designed to establish the onset of anorexia and related symptoms. Food intake was evaluated using a three-day diet diary. BDI, SI, STAI-T, and STAI-S were used to assess mood state. The administration of 5-hydroxytryptophan resulted in no changes in mood state but promoted typical anorexia-related symptoms, decreased food intake and weight loss during the period of observation.
THE EFFECTS OF ORAL 5-HYDROXYTRYPTOPHAN ADMINISTRATION ON FEEDING-BEHAVIOR IN OBESE ADULT FEMALE SUBJECTS / Ceci, Fabrizio; Cangiano, Carlo Oreste; Cairella, Michelangelo; Cascino, Antonia; DEL BEN, Maria; Muscaritoli, Maurizio; Sibilia, Lucio; ROSSI FANELLI, Filippo. - In: JOURNAL OF NEURAL TRANSMISSION. - ISSN 0300-9564. - STAMPA. - 76:2(1989), pp. 109-117. [10.1007/bf01578751]
THE EFFECTS OF ORAL 5-HYDROXYTRYPTOPHAN ADMINISTRATION ON FEEDING-BEHAVIOR IN OBESE ADULT FEMALE SUBJECTS
CECI, Fabrizio;CANGIANO, Carlo Oreste;CAIRELLA, Michelangelo;CASCINO, Antonia;DEL BEN, Maria;MUSCARITOLI, Maurizio;SIBILIA, Lucio;ROSSI FANELLI, Filippo
1989
Abstract
Nineteen obese female subjects with body mass index ranging between 30 and 40 were included in a double-blind crossover study aimed at evaluating the effects of oral 5-hydroxytryptophan administration on feeding behavior, mood state and weight loss. Either 5-hydroxytryptophan (8 mg/kg/day) or placebo was administered for five weeks during which patients were not prescribed any dietary restrictions. Feeding behavior was investigated by means of a questionnaire designed to establish the onset of anorexia and related symptoms. Food intake was evaluated using a three-day diet diary. BDI, SI, STAI-T, and STAI-S were used to assess mood state. The administration of 5-hydroxytryptophan resulted in no changes in mood state but promoted typical anorexia-related symptoms, decreased food intake and weight loss during the period of observation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
