One hundred patients with primary hypercholesterolemia (total plasma cholesterol greater than or equal to 6.2 mmol/L [240 mg/dl]) were enrolled in an open, randomized, parallel comparative study of simvastatin and pravastatin. All patients started or continued a standard lipid-lowering diet for at least six weeks prior to entry into the four-week placebo baseline period. Fifty patients received simvastatin and 50 patients received pravastatin, both at the recommended starting dose of 10 mg/day, for a treatment period of six weeks. Total cholesterol levels were reduced by 24\% (from 7.59 mmol/L to 5.80 mmol/L) with simvastatin, and by 15\% (from 7.48 mmol/L to 6.35 mmol/L) with pravastatin. Low-density-lipoprotein cholesterol levels were reduced by 33\% and 22\% and high-density-lipoprotein cholesterol levels were increased by 10\% and 7\% with simvastatin and pravastatin, respectively. Plasma total triglyceride levels were reduced by 12\% with simvastatin and by 6\% with pravastatin. Adverse experiences were similar between treatment groups and both drugs were well tolerated. No patients were withdrawn from the study due to clinical adverse experiences; one patient in the pravastatin group required a reduction in dose to 5 mg/day due to insomnia. At the recommended starting dose, simvastatin had a significantly greater lipid-lowering effect than pravastatin. These results may have implications for the appropriate lipid-reduction therapy for patients at risk of coronary heart disease.
Simvastatin versus pravastatin: efficacy and tolerability in patients with primary hypercholesterolemia / P. L., Malini; E., Ambrosioni; O. D., Divitiis; DI SOMMA, Salvatore; G., Rosiello; B., Trimarco. - In: CLINICAL THERAPEUTICS. - ISSN 0149-2918. - STAMPA. - 13:(1991), pp. 500-510.
Simvastatin versus pravastatin: efficacy and tolerability in patients with primary hypercholesterolemia.
DI SOMMA, Salvatore;
1991
Abstract
One hundred patients with primary hypercholesterolemia (total plasma cholesterol greater than or equal to 6.2 mmol/L [240 mg/dl]) were enrolled in an open, randomized, parallel comparative study of simvastatin and pravastatin. All patients started or continued a standard lipid-lowering diet for at least six weeks prior to entry into the four-week placebo baseline period. Fifty patients received simvastatin and 50 patients received pravastatin, both at the recommended starting dose of 10 mg/day, for a treatment period of six weeks. Total cholesterol levels were reduced by 24\% (from 7.59 mmol/L to 5.80 mmol/L) with simvastatin, and by 15\% (from 7.48 mmol/L to 6.35 mmol/L) with pravastatin. Low-density-lipoprotein cholesterol levels were reduced by 33\% and 22\% and high-density-lipoprotein cholesterol levels were increased by 10\% and 7\% with simvastatin and pravastatin, respectively. Plasma total triglyceride levels were reduced by 12\% with simvastatin and by 6\% with pravastatin. Adverse experiences were similar between treatment groups and both drugs were well tolerated. No patients were withdrawn from the study due to clinical adverse experiences; one patient in the pravastatin group required a reduction in dose to 5 mg/day due to insomnia. At the recommended starting dose, simvastatin had a significantly greater lipid-lowering effect than pravastatin. These results may have implications for the appropriate lipid-reduction therapy for patients at risk of coronary heart disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.