Histological lesions in the testis of infertile men with varicocele

Varicocele frequently causes male infertility and histological lesions at the contralateral testis. The most frequent lesions found in this included maturation arrest in the spermatidic phase, cellular and acellular thickening of the tubular wall, and degeneration of the Leydig cells. These lesions were typical of varicocele and their simultaneous presence suggests that scrotal temperature and modified endocrine secretion of the interstitial testis play a role in the pathogenesis of this type of infertility.