End-stage liver disease (ESLD) and chronic kidney disease (CKD) patients are both immunocompromised populations but polyomavirus BK (BKV) replication before liver transplantation is rare. We evaluated BKV prevalence among liver transplant recipients with renal dysfunction and the possible role of CKD as a risk factor for BKV replication in ESLD. From 2010 to 2011 we selected 31 ESLD patients awaiting liver transplantation to identify, the presence of CKD: No CKD (n = 22; 18 males) and CKD group (n = 9; 5 males). BKV infection was defined on the basis of viremia evaluated using quantitative real-time polymerase chain reactions. The prevalence of viremia among the No CKD group was 14% versus 56% in the CKD group (Fisher test; P =.027). We hypothesized that the presence of CKD may represent an additional condition of immunologic dysfunction regarding antiviral surveillances other than the antibacterial one that characterizes ESLD immunodysfunction, which could have promoted BKV replication. The specific immunologic mechanisms involved in pretransplantation diseases may have a role in BKV reactivation that could become responsible for nephropathy after transplantation. © 2012 Published by Elsevier Inc.

Polyomavirus BK infection before liver transplantation in patients with chronic kidney disease / Mitterhofer, Anna Paola; Tinti, Francesca; Umbro, Ilaria; Pietropaolo, Valeria Antonietta; F., Fiacco; Bellizzi, Anna; Anzivino, Elena; GINANNI CORRADINI, Stefano; Stefano Ginanni, Corradini; Poli, Luca; Rossi, Massimo; Berloco, Pasquale Bartolomeo; G., Ferretti; Chiarini, Fernanda; Taliani, Gloria. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - ELETTRONICO. - 44:7(2012), pp. 1934-1937. [10.1016/j.transproceed.2012.06.052]

Polyomavirus BK infection before liver transplantation in patients with chronic kidney disease.

MITTERHOFER, Anna Paola;TINTI, FRANCESCA;UMBRO, ILARIA;PIETROPAOLO, Valeria Antonietta;BELLIZZI, ANNA;ANZIVINO, ELENA;GINANNI CORRADINI, Stefano;POLI, Luca;ROSSI, MASSIMO;BERLOCO, Pasquale Bartolomeo;CHIARINI, Fernanda;TALIANI, Gloria
2012

Abstract

End-stage liver disease (ESLD) and chronic kidney disease (CKD) patients are both immunocompromised populations but polyomavirus BK (BKV) replication before liver transplantation is rare. We evaluated BKV prevalence among liver transplant recipients with renal dysfunction and the possible role of CKD as a risk factor for BKV replication in ESLD. From 2010 to 2011 we selected 31 ESLD patients awaiting liver transplantation to identify, the presence of CKD: No CKD (n = 22; 18 males) and CKD group (n = 9; 5 males). BKV infection was defined on the basis of viremia evaluated using quantitative real-time polymerase chain reactions. The prevalence of viremia among the No CKD group was 14% versus 56% in the CKD group (Fisher test; P =.027). We hypothesized that the presence of CKD may represent an additional condition of immunologic dysfunction regarding antiviral surveillances other than the antibacterial one that characterizes ESLD immunodysfunction, which could have promoted BKV replication. The specific immunologic mechanisms involved in pretransplantation diseases may have a role in BKV reactivation that could become responsible for nephropathy after transplantation. © 2012 Published by Elsevier Inc.
2012
liver transplantation; renal transplantation; chronic kidney disease; polyomavirus bk
01 Pubblicazione su rivista::01a Articolo in rivista
Polyomavirus BK infection before liver transplantation in patients with chronic kidney disease / Mitterhofer, Anna Paola; Tinti, Francesca; Umbro, Ilaria; Pietropaolo, Valeria Antonietta; F., Fiacco; Bellizzi, Anna; Anzivino, Elena; GINANNI CORRADINI, Stefano; Stefano Ginanni, Corradini; Poli, Luca; Rossi, Massimo; Berloco, Pasquale Bartolomeo; G., Ferretti; Chiarini, Fernanda; Taliani, Gloria. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - ELETTRONICO. - 44:7(2012), pp. 1934-1937. [10.1016/j.transproceed.2012.06.052]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/443584
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