Aminoethylcysteine ketimine decarboxylated dimer is a natural compound with antioxidant properties of a new family of sulfur-containing amino acids. It has been detected in human urine and plasma, in mammalian cerebellum and in dietary vegetables. In this study we firstly demonstrate the absorption of aminoethylcysteine ketimine decarboxylated dimer in mice from aminoethylcysteine ketimine decarboxylated dimer-supplemented diet, using both liquid chromatography with electrochemical detection and gaschromatography coupled with mass spectrometry. Aminoethylcysteine ketimine decarboxylated dimer circulate in plasma of supplemented mice at micromolar concentration and is actively incorporated in liver tissues. The absorption of AECK-DD is dose and time-dependent. The dehydrogenation products of AECK-DD was also identified in plasma and liver of mice fed the AECK-DD-supplemented diet. A significant increase in plasma antioxidant potential was measured in mice fed aminoethylcysteine ketimine decarboxylated dimer-supplemented diet in respect to mice fed the control diet. These results demonstrate for the first time the absorption of aminoethylcysteine ketimine decarboxylated dimer from diet and the physiological relevance of this compound through its antioxidant action in vivo.
Absorption of aminoethylcysteine ketimine decarboxylated dimer in mice / M., Nardini; A., Piazzon; Macone, Alberto; Matarese, Rosa Marina; A., Finamore. - In: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. - ISSN 0021-8561. - STAMPA. - 60:---(2012), pp. 4596-4602. [10.1021/jf300510m]
Absorption of aminoethylcysteine ketimine decarboxylated dimer in mice.
MACONE, ALBERTO;MATARESE, Rosa Marina;
2012
Abstract
Aminoethylcysteine ketimine decarboxylated dimer is a natural compound with antioxidant properties of a new family of sulfur-containing amino acids. It has been detected in human urine and plasma, in mammalian cerebellum and in dietary vegetables. In this study we firstly demonstrate the absorption of aminoethylcysteine ketimine decarboxylated dimer in mice from aminoethylcysteine ketimine decarboxylated dimer-supplemented diet, using both liquid chromatography with electrochemical detection and gaschromatography coupled with mass spectrometry. Aminoethylcysteine ketimine decarboxylated dimer circulate in plasma of supplemented mice at micromolar concentration and is actively incorporated in liver tissues. The absorption of AECK-DD is dose and time-dependent. The dehydrogenation products of AECK-DD was also identified in plasma and liver of mice fed the AECK-DD-supplemented diet. A significant increase in plasma antioxidant potential was measured in mice fed aminoethylcysteine ketimine decarboxylated dimer-supplemented diet in respect to mice fed the control diet. These results demonstrate for the first time the absorption of aminoethylcysteine ketimine decarboxylated dimer from diet and the physiological relevance of this compound through its antioxidant action in vivo.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.