This review describes the state-of-art in the field of the gas-phase reactivity of diastereomeric complexes formed between a chiral artificial receptor and a biologically active molecule. The presented experimental approach is a ligand-displacement reaction carried out in a nano ESI-FT-ICR instrument, supported by a thermodynamic MS-study and molecular-mechanics and molecular-dynamics (MM/MD) computational techniques. The noncovalent ion-molecule complexes are ideal for the study of chiral recognition in the absence of complicating solvent and counterion effects. © 2012 Fraschetti et al.
Enantioselective supramolecular devices in the gas phase. Resorcin[4]arene as a model system / Fraschetti, Caterina; C., Letzel Matthias; Filippi, Antonello; Speranza, Maurizio; Jochen, Mattay. - In: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1860-5397. - ELETTRONICO. - 8:(2012), pp. 539-550. [10.3762/bjoc.8.62]
Enantioselective supramolecular devices in the gas phase. Resorcin[4]arene as a model system
FRASCHETTI, CATERINA;FILIPPI, Antonello;SPERANZA, Maurizio;
2012
Abstract
This review describes the state-of-art in the field of the gas-phase reactivity of diastereomeric complexes formed between a chiral artificial receptor and a biologically active molecule. The presented experimental approach is a ligand-displacement reaction carried out in a nano ESI-FT-ICR instrument, supported by a thermodynamic MS-study and molecular-mechanics and molecular-dynamics (MM/MD) computational techniques. The noncovalent ion-molecule complexes are ideal for the study of chiral recognition in the absence of complicating solvent and counterion effects. © 2012 Fraschetti et al.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
