This review describes the state-of-art in the field of the gas-phase reactivity of diastereomeric complexes formed between a chiral artificial receptor and a biologically active molecule. The presented experimental approach is a ligand-displacement reaction carried out in a nano ESI-FT-ICR instrument, supported by a thermodynamic MS-study and molecular-mechanics and molecular-dynamics (MM/MD) computational techniques. The noncovalent ion-molecule complexes are ideal for the study of chiral recognition in the absence of complicating solvent and counterion effects. © 2012 Fraschetti et al.

Enantioselective supramolecular devices in the gas phase. Resorcin[4]arene as a model system / Fraschetti, Caterina; C., Letzel Matthias; Filippi, Antonello; Speranza, Maurizio; Jochen, Mattay. - In: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1860-5397. - ELETTRONICO. - 8:(2012), pp. 539-550. [10.3762/bjoc.8.62]

Enantioselective supramolecular devices in the gas phase. Resorcin[4]arene as a model system

FRASCHETTI, CATERINA;FILIPPI, Antonello;SPERANZA, Maurizio;
2012

Abstract

This review describes the state-of-art in the field of the gas-phase reactivity of diastereomeric complexes formed between a chiral artificial receptor and a biologically active molecule. The presented experimental approach is a ligand-displacement reaction carried out in a nano ESI-FT-ICR instrument, supported by a thermodynamic MS-study and molecular-mechanics and molecular-dynamics (MM/MD) computational techniques. The noncovalent ion-molecule complexes are ideal for the study of chiral recognition in the absence of complicating solvent and counterion effects. © 2012 Fraschetti et al.
2012
diastereomeric complexes; gas phase enantioselectivity; kinetics; mass spectrometry; resorcin[4]arene receptor
01 Pubblicazione su rivista::01a Articolo in rivista
Enantioselective supramolecular devices in the gas phase. Resorcin[4]arene as a model system / Fraschetti, Caterina; C., Letzel Matthias; Filippi, Antonello; Speranza, Maurizio; Jochen, Mattay. - In: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1860-5397. - ELETTRONICO. - 8:(2012), pp. 539-550. [10.3762/bjoc.8.62]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/443475
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