A number of landmark trials have proven the efficacy of thrombolysis by intravenous recombinant tissue plasminogen activator in the acute phase of the ischemic stroke. Despite the recently extended time window of 4.5 hours, the number of people who are being treated in most centers is low. Several reasons seem to account for this, including poor recognition of symptoms, delays in emergency transport, low levels of public awareness, or age limits originally imposed by drug regulatory rules. Trials are ongoing to possibly extend the indications to the treatment. A major effort is to extend the time window by bridging the treatment with neuroprotective approaches, or by identifying subgroups that may particularly benefit from recanalization and reperfusion. Procedures using ultrasounds or alternative intravenous compounds are also being investigated with promising results. © 2012 Elsevier Inc.

Current indications and results of thrombolysis by intravenous recombinant tissue plasminogen activator / TARI CAPONE, Francesca; Cavallari, Michele; Casolla, Barbara; Orzi, Francesco. - In: TECHNIQUES IN VASCULAR AND INTERVENTIONAL RADIOLOGY. - ISSN 1089-2516. - STAMPA. - 15:1(2012), pp. 10-18. [10.1053/j.tvir.2011.12.002]

Current indications and results of thrombolysis by intravenous recombinant tissue plasminogen activator.

TARI CAPONE, FRANCESCA;CAVALLARI, MICHELE;CASOLLA, BARBARA;ORZI, Francesco
2012

Abstract

A number of landmark trials have proven the efficacy of thrombolysis by intravenous recombinant tissue plasminogen activator in the acute phase of the ischemic stroke. Despite the recently extended time window of 4.5 hours, the number of people who are being treated in most centers is low. Several reasons seem to account for this, including poor recognition of symptoms, delays in emergency transport, low levels of public awareness, or age limits originally imposed by drug regulatory rules. Trials are ongoing to possibly extend the indications to the treatment. A major effort is to extend the time window by bridging the treatment with neuroprotective approaches, or by identifying subgroups that may particularly benefit from recanalization and reperfusion. Procedures using ultrasounds or alternative intravenous compounds are also being investigated with promising results. © 2012 Elsevier Inc.
2012
rt-pa; thrombolysis; acute ischemic stroke
01 Pubblicazione su rivista::01a Articolo in rivista
Current indications and results of thrombolysis by intravenous recombinant tissue plasminogen activator / TARI CAPONE, Francesca; Cavallari, Michele; Casolla, Barbara; Orzi, Francesco. - In: TECHNIQUES IN VASCULAR AND INTERVENTIONAL RADIOLOGY. - ISSN 1089-2516. - STAMPA. - 15:1(2012), pp. 10-18. [10.1053/j.tvir.2011.12.002]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/441625
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