Estrogens have long been associated with the processes involved in prostate carcinogenesis, particularly in cancer suppression. However, the synergistic influence of low concentrations of estrogens, together with androgens, in promoting aberrant growth of the gland has also been recognized. As new insights into the complex molecular events implicated in growth regulation of the prostate are revealed, the role of the estrogens has become clearer. The present review considers this role in relation to the pathogenesis of prostate cancer and the potential cancer-repressive influence of the dietary estrogens.
Estrogens and aspects of prostate disease / Domenico, Prezioso; Denis, Lj; Helmut, Klocker; Sciarra, Alessandro; Mario, Reis; Kurt, Naber; Bernard, Lobel; Dalibor, Pacik; Keith, Griffiths. - In: INTERNATIONAL JOURNAL OF UROLOGY. - ISSN 0919-8172. - 14:1(2007), pp. 1-16. [10.1111/j.1442-2042.2006.01476.x]
Estrogens and aspects of prostate disease
SCIARRA, Alessandro;
2007
Abstract
Estrogens have long been associated with the processes involved in prostate carcinogenesis, particularly in cancer suppression. However, the synergistic influence of low concentrations of estrogens, together with androgens, in promoting aberrant growth of the gland has also been recognized. As new insights into the complex molecular events implicated in growth regulation of the prostate are revealed, the role of the estrogens has become clearer. The present review considers this role in relation to the pathogenesis of prostate cancer and the potential cancer-repressive influence of the dietary estrogens.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
