Background:: This study assessed the effect of a systemic oral treatment with antioxidants (AOs) in preretinopathic diabetes (PRD) patients, through the evaluation of oxidative stress in plasma and changes in the full-field electroretinogram (ERG). Methods: Thirty-two PRD subjects with good metabolic control were recruited. Patients were randomized in two groups, one of which received oral AO treatment with alpha-lipoic acid at 400 mg/day in association with genistein and vitamins, whereas the other group received a placebo. Free radicals and the AO barrier were evaluated in plasma with the Free Radical Analytical System 4 instrument (H&D srl, Parma, Italy), and the same day the electrophysiological response was measured by ERG. These analyses were performed at enrollment and after 30 days of treatment. Results: Statistically significant increases of plasma AO levels and ERG oscillatory potential values were observed in the group treated with AO, but not in the control group. Conclusions: Results of this preliminary study suggest that an oral treatment with AOs in PRD subjects may have a protective effect on retinal cells, as detected by ERG analysis, through the strengthening of the plasma AO barrier.
Oxidative stress in pre-retinopathic diabetic subjects and antioxidants / Nebbioso, Marcella; M., Federici; D., Rusciano; M., Evangelista; Pescosolido, Nicola. - In: DIABETES TECHNOLOGY & THERAPEUTICS. - ISSN 1520-9156. - STAMPA. - 14:3(2012), pp. 257-263.
|Titolo:||Oxidative stress in pre-retinopathic diabetic subjects and antioxidants|
NEBBIOSO, Marcella (Primo) [Writing – Review & Editing] (Corresponding author)
|Data di pubblicazione:||2012|
|Citazione:||Oxidative stress in pre-retinopathic diabetic subjects and antioxidants / Nebbioso, Marcella; M., Federici; D., Rusciano; M., Evangelista; Pescosolido, Nicola. - In: DIABETES TECHNOLOGY & THERAPEUTICS. - ISSN 1520-9156. - STAMPA. - 14:3(2012), pp. 257-263.|
|Appartiene alla tipologia:||01l Trial clinico|
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