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EnglishPeripheral blood T lymphocytes and T-cell subsets were analyzed in 19 patients with HBV-associated chronic liver disease, in 9 "autoimmune" chronic active hepatitis patients, and in three patients with HBV acute hepatitis. The percentages of the different T-cell subpopulations were defined by indirect immunofluorescence using monoclonal antibodies against all peripheral blood T cells (OKT3), T helper cells (OKT4), T suppressor cytotoxic cells (OKT8), and Ia antigens (OKIa1). The OKT4/OKT8 ratio was significantly lower in HBsAg+ chronic liver disease patients as compared with controls (P < 0.001), with both decreases of T helper cells and increases of T suppressor cells while "autoimmune" chronic active hepatitis patients showed a significantly increased ratio (P< 0.001). Acute HBV infection was associated with a reversal in the normal ratio of helper to suppressor T lymphocytes. During convalescence helper T lymphocytes increased and suppressor T lymphocytes decreased. © 1983.
Immunoregulatory T cells in HBV-induced chronic liver disease as defined by monoclonal antibodies / Barnaba, Vincenzo; C., Zaccari; Levrero, Massimo; G., Ruocco; F., Balsano. - In: CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY. - ISSN 0090-1229. - 26:1(1983), pp. 83-90.
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| Titolo: | Immunoregulatory T cells in HBV-induced chronic liver disease as defined by monoclonal antibodies | |
| Autori: | ||
| Data di pubblicazione: | 1983 | |
| Rivista: | ||
| Citazione: | Immunoregulatory T cells in HBV-induced chronic liver disease as defined by monoclonal antibodies / Barnaba, Vincenzo; C., Zaccari; Levrero, Massimo; G., Ruocco; F., Balsano. - In: CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY. - ISSN 0090-1229. - 26:1(1983), pp. 83-90. | |
| Handle: | http://hdl.handle.net/11573/438621 | |
| Appartiene alla tipologia: | 01a Articolo in rivista |
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