The relationship between T cell subset, as defined by monoclonal antibodies, and suppressor cell function, using a short lived suppressor cell assay, was studied in 38 chronic hepatitis B virus (HBV) carriers and in 32 patients with HBsAg negative chronic active hepatitis (CAH). Patients with HBV chronic infection showed an absolute reduction in the OKT4 positive subset and a significantly decreased OKT4/OKT8 ratio, as compared with healthy controls. Patients with anti-nuclear antibodies (ANA) and anti-smooth muscle antibodies (ASMA) positive CAH with or without antibodies to HBV antigens, namely anti-HBs and anti-HBc, demonstrated a significant reduction in cytotoxic/suppressor T cells and an increase helper/suppressor ratio. A negative correlation between suppressor index (SI) and OKT4/OKT8 ratio (P<0.01), and a positive correlation between SI and OKT8 positive cells absolute number (P<0.01) were also observed.
Relationship between T cell subsets and suppressor cell activity in chronic hepatitis B virus (HBV) infection / Barnaba, Vincenzo; A., Musca; C., Cordova; Levrero, Massimo; G., Ruocco; V., Albertini Petroni; F., Balsano. - In: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. - ISSN 0009-9104. - 53:2(1983), pp. 281-288.
Relationship between T cell subsets and suppressor cell activity in chronic hepatitis B virus (HBV) infection
BARNABA, Vincenzo;LEVRERO, Massimo;
1983
Abstract
The relationship between T cell subset, as defined by monoclonal antibodies, and suppressor cell function, using a short lived suppressor cell assay, was studied in 38 chronic hepatitis B virus (HBV) carriers and in 32 patients with HBsAg negative chronic active hepatitis (CAH). Patients with HBV chronic infection showed an absolute reduction in the OKT4 positive subset and a significantly decreased OKT4/OKT8 ratio, as compared with healthy controls. Patients with anti-nuclear antibodies (ANA) and anti-smooth muscle antibodies (ASMA) positive CAH with or without antibodies to HBV antigens, namely anti-HBs and anti-HBc, demonstrated a significant reduction in cytotoxic/suppressor T cells and an increase helper/suppressor ratio. A negative correlation between suppressor index (SI) and OKT4/OKT8 ratio (P<0.01), and a positive correlation between SI and OKT8 positive cells absolute number (P<0.01) were also observed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.