Interaction oi the p55 tumor necrosis factor receptor 1 (TNF-R1)-associated signal transducer TRADD with FADD signals apoptosis, whereas the TNF receptor-associated factor 2 protein (TRAF2) is required for activation of the nuclear transcription factor nuclear factor kappa B. TNF-induced activation of the stress-activated protein kinase (SAPK) was shown to occur through a noncytotoxic TRAF2-dependent pathway. TRAF2 was both sufficient and necessary for activation of SAPK by TNF-R1; conversely, expression of a dominant-negative FADD mutant, which blocks apoptosis, did not interfere with SAPK activation. Therefore, SAPK activation occurs through a pathway that is not required for TNF-R1-induced apoptosis.

Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway / G., Natoli; A., Costanzo; A., Ianni; D. J., Templeton; J. R., Woodgett; C., Balsano; Levrero, Massimo. - In: SCIENCE. - ISSN 0036-8075. - 275:5297(1997), pp. 200-203. [10.1126/science.275.5297.200]

Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway

LEVRERO, Massimo
1997

Abstract

Interaction oi the p55 tumor necrosis factor receptor 1 (TNF-R1)-associated signal transducer TRADD with FADD signals apoptosis, whereas the TNF receptor-associated factor 2 protein (TRAF2) is required for activation of the nuclear transcription factor nuclear factor kappa B. TNF-induced activation of the stress-activated protein kinase (SAPK) was shown to occur through a noncytotoxic TRAF2-dependent pathway. TRAF2 was both sufficient and necessary for activation of SAPK by TNF-R1; conversely, expression of a dominant-negative FADD mutant, which blocks apoptosis, did not interfere with SAPK activation. Therefore, SAPK activation occurs through a pathway that is not required for TNF-R1-induced apoptosis.
1997
01 Pubblicazione su rivista::01a Articolo in rivista
Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway / G., Natoli; A., Costanzo; A., Ianni; D. J., Templeton; J. R., Woodgett; C., Balsano; Levrero, Massimo. - In: SCIENCE. - ISSN 0036-8075. - 275:5297(1997), pp. 200-203. [10.1126/science.275.5297.200]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/438568
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