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EnglishThe presence of large pigmented, lipid-laden histiocytes throughout the reticuloendothelium is a typical feature of CGD. They have been studied histochemically in specimens of spleen, liver and lymph nodes of a 17-year-old female with CGD. The results of such a study indicate that in CGD histiocytes contain a ceroid pigment. The typical autofluorescence of the pigment is related to lipid peroxidation-derived fluorescent compounds, which seem to be directly involved in the PFAS-positivity of ceroid. This suggests that PFAS stain can be considered not only a technique for the demonstration of unsaturated lipids, but also a useful histochemical method in the study of lipid peroxidation. The finding of ceroid storage, which always indicates an excess of free-radical reactions in vivo, is particularly intriguing in CDG, known to be characterized by the failure of a free-radical generating enzymatic system in phagocytes.
A histochemical study of lipoid pigment storage in chronic granulomatous disease (CGD) / Bianco, Paolo. - In: BASIC AND APPLIED HISTOCHEMISTRY. - ISSN 0391-7258. - 27:1(1983), pp. 35-43.
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| Titolo: | A histochemical study of lipoid pigment storage in chronic granulomatous disease (CGD) | |
| Autori: | ||
| Data di pubblicazione: | 1983 | |
| Rivista: | ||
| Citazione: | A histochemical study of lipoid pigment storage in chronic granulomatous disease (CGD) / Bianco, Paolo. - In: BASIC AND APPLIED HISTOCHEMISTRY. - ISSN 0391-7258. - 27:1(1983), pp. 35-43. | |
| Handle: | http://hdl.handle.net/11573/438461 | |
| Appartiene alla tipologia: | 01a Articolo in rivista |
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http://hdl.handle.net/11573/438461
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