Ten patients with hairy cell leukemia are being treated at our institution with a therapeutic schedule of alpha 2(r) interferon (2 X 10(6) IU/m2 s.c. three times per week). Five patients underwent splenectomy from 4 to 108 months before treatment; nonsplenectomized patients had spleens palpable 6 to 12 cm UCM. According to Quesada's response criteria, at the sixth month of therapy, one patient was considered a complete responder, 8 partial responders and one a minor responder, with no differences between splenectomized and nonsplenectomized patients. In nonsplenectomized patients the spleen returned to normal. Our data confirm that interferon, even at low dosages, is a very effective approach for hairy cell leukemia. No evidence was found to contraindicate such therapy.
Hairy cell leukemia: preliminary results with alpha 2 (r) interferon / Mandelli, F; Annino, L; Cafolla, Arturo; De Rossi, G; Bianco, Paolo; Fontana, L; Dianzani, F.. - In: TUMORI. - ISSN 0300-8916. - 72:(1986), pp. 153-156.
Hairy cell leukemia: preliminary results with alpha 2 (r) interferon.
CAFOLLA, Arturo;BIANCO, Paolo;
1986
Abstract
Ten patients with hairy cell leukemia are being treated at our institution with a therapeutic schedule of alpha 2(r) interferon (2 X 10(6) IU/m2 s.c. three times per week). Five patients underwent splenectomy from 4 to 108 months before treatment; nonsplenectomized patients had spleens palpable 6 to 12 cm UCM. According to Quesada's response criteria, at the sixth month of therapy, one patient was considered a complete responder, 8 partial responders and one a minor responder, with no differences between splenectomized and nonsplenectomized patients. In nonsplenectomized patients the spleen returned to normal. Our data confirm that interferon, even at low dosages, is a very effective approach for hairy cell leukemia. No evidence was found to contraindicate such therapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.