A 2.4-kb) stretch within the RRM2P4 region of the X chromosome, previously sequenced in a sample of 41 globally distributed humans, displayed both an ancient. time to the most recent. common ancestor (e.g., a TMRCA of similar to 2 million years) and a basal clade composed entire]), of Asian sequences. This pattern was interpreted to reflect a history of introgressive hybridization from archaic hominins (most likely Asian Homo ereclus) into the anatomically modern human genome. Here, we address this hypothesis by resequencing( the 2.4-ki) RRM2P4 region in 131 African and 122 non-African individuals and by extending the length of sequence in a ,inof 16.5 kb encompassing the RRM2P4 pseudogene in a subset of 90 individuals. We find that both the ancient TMRCA and the skew in non-African representation in one of the basal clades are essentially limited to the central 2.4-kb region. We define a new summary statistic called the minimum clade proportion (P(mc)), which quantifies the proportion of individuals front a specified geographic region in each of the two basal clades of a binary gene tree, and then employ coalescent simulations to assess the likelihood of the observed central RRM2P4, genealogy Under two alternative views Of human evolutionary history: recent. African replacement (RAR) and archaic admixture (AA). A molecular lar-clock-based TMRCA estimate of 2.33 million years is a statistical outlier Under the RAR model; however, the large variance associated With this estimate makes it difficult to distinguish the predictions of the human origins models tested here. The P(mc) summary statistic, which, has inipimproved power with larger samples of chromosomes, yields values that are significant], unlikely under the RAR imodel and fit expectations better under a range of archaic admixture scenarios.
Testing for archaic hominin admixture on the X chromosome: Model likelihoods for the modern human RRM2P4 region from summaries of genealogical topology under the structured coalescent / M. P., Cox; F. L., Mendez; T. M., Karafet; M. M., Pilkington; S. B., Kingan; DESTRO-BISOL, Giovanni; B. I., Strassmann; M. F., Hammer. - In: GENETICS. - ISSN 0016-6731. - STAMPA. - 178:1(2008), pp. 427-437. [10.1534/genetics.107.080432]
Testing for archaic hominin admixture on the X chromosome: Model likelihoods for the modern human RRM2P4 region from summaries of genealogical topology under the structured coalescent
DESTRO-BISOL, Giovanni;
2008
Abstract
A 2.4-kb) stretch within the RRM2P4 region of the X chromosome, previously sequenced in a sample of 41 globally distributed humans, displayed both an ancient. time to the most recent. common ancestor (e.g., a TMRCA of similar to 2 million years) and a basal clade composed entire]), of Asian sequences. This pattern was interpreted to reflect a history of introgressive hybridization from archaic hominins (most likely Asian Homo ereclus) into the anatomically modern human genome. Here, we address this hypothesis by resequencing( the 2.4-ki) RRM2P4 region in 131 African and 122 non-African individuals and by extending the length of sequence in a ,inof 16.5 kb encompassing the RRM2P4 pseudogene in a subset of 90 individuals. We find that both the ancient TMRCA and the skew in non-African representation in one of the basal clades are essentially limited to the central 2.4-kb region. We define a new summary statistic called the minimum clade proportion (P(mc)), which quantifies the proportion of individuals front a specified geographic region in each of the two basal clades of a binary gene tree, and then employ coalescent simulations to assess the likelihood of the observed central RRM2P4, genealogy Under two alternative views Of human evolutionary history: recent. African replacement (RAR) and archaic admixture (AA). A molecular lar-clock-based TMRCA estimate of 2.33 million years is a statistical outlier Under the RAR model; however, the large variance associated With this estimate makes it difficult to distinguish the predictions of the human origins models tested here. The P(mc) summary statistic, which, has inipimproved power with larger samples of chromosomes, yields values that are significant], unlikely under the RAR imodel and fit expectations better under a range of archaic admixture scenarios.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.