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EnglishA case of chronic cold-haemagglutinin disease is reported in which an agglutinin apparently carrying two specificities was present. At first, specificity was anti-not-I and anti-I respectively: in the course of time anti-I was replaced by anti-A-1. Both anti-I and anti-A-1 could be demonstrated at room temperature only while specificity was anti-not-I at 4 degrees C. The antibody displayed haemolytic activity at room temperature and gave stronger reactions when treated biphasically. The same pattern of specificity was apparent in haemolysis tests, i.e. anti-not-I in the biphasical reaction 4 degrees C goes to 37 degrees C and first anti-I and later anti-A-1 at room temperature and at 22 degrees C goes to 37 degrees C. Anti-A-1 was not neutralized by A bloodgroup substance of animal origin nor by secretor saliva.
Cold-haemagglutinin disease with an autoantibody exhibiting different specificities at different temperatures / Boccardi, V; Girelli, Gabriella; Zappi, P.. - In: SCANDINAVIAN JOURNAL OF HAEMATOLOGY. - ISSN 0036-553X. - STAMPA. - 14(1975), pp. 268-276.
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| Titolo: | Cold-haemagglutinin disease with an autoantibody exhibiting different specificities at different temperatures. | |
| Autori: | ||
| Data di pubblicazione: | 1975 | |
| Rivista: | ||
| Citazione: | Cold-haemagglutinin disease with an autoantibody exhibiting different specificities at different temperatures / Boccardi, V; Girelli, Gabriella; Zappi, P.. - In: SCANDINAVIAN JOURNAL OF HAEMATOLOGY. - ISSN 0036-553X. - STAMPA. - 14(1975), pp. 268-276. | |
| Handle: | http://hdl.handle.net/11573/437975 | |
| Appartiene alla tipologia: | 01a Articolo in rivista |
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