Antiglobulin test (AT) and Dixon tests were performed in 100 patients with CLL. Thirty-five of them had Rai stages 0 or 1, 19 stage 2, 13 stage 3, and 33 stage 4. Twelve patients showed red blood cells autoantibodies (RBCAb) positivity; positivity at Dixon test (direct, indirect, or both) was observed in 74 %. The presence of autoantibodies against erythrocytes and platelets did not influence survival curves, but anemia and thrombocytopenia are considered risk factors, independently of the presence of an autoimmune disorder. Nine RBCAb positive patients with positive Dixon test had the worst survival curves, 5 of these were anemic and 1 thrombocytopenic and anemic.
Prognostic value of autoantibodies against erythrocytes and platelets in chronic lymphocytic leukemia (CLL) / De Rossi, G; Granati, Lucia; Girelli, Gabriella; Gandolo, G; Perrone, P; Martelli, Maurizio; Conti, L; Marini, R; Pastorelli, D; Coluzzi, S; Niscola, P; Pizzo, F; Mandelli, Franco. - In: TUMORI. - ISSN 0300-8916. - STAMPA. - 77:(1991), pp. 100-104.
Prognostic value of autoantibodies against erythrocytes and platelets in chronic lymphocytic leukemia (CLL).
GRANATI, Lucia;GIRELLI, Gabriella;MARTELLI, Maurizio;Coluzzi S;MANDELLI, Franco
1991
Abstract
Antiglobulin test (AT) and Dixon tests were performed in 100 patients with CLL. Thirty-five of them had Rai stages 0 or 1, 19 stage 2, 13 stage 3, and 33 stage 4. Twelve patients showed red blood cells autoantibodies (RBCAb) positivity; positivity at Dixon test (direct, indirect, or both) was observed in 74 %. The presence of autoantibodies against erythrocytes and platelets did not influence survival curves, but anemia and thrombocytopenia are considered risk factors, independently of the presence of an autoimmune disorder. Nine RBCAb positive patients with positive Dixon test had the worst survival curves, 5 of these were anemic and 1 thrombocytopenic and anemic.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
