A 73-year-old man with hydatid disease developed autoimmune hemolytic anemia due to IgM cold agglutinin with anti-I specificity. Hemolysis decreased after initiating mebendazole therapy. The cysts notably diminished in size and the red cell autoantibodies disappeared at the end of this treatment. On the basis of these observations, 44 patients with hydatid disease were investigated. One patient showed IgM cold autoantibody with no signs of anemia. In addition, cleavage fragments of C3 were detected on the erythrocyte membranes of 6 patients, following chronic activation of the complement system. We suggest that parasitic antigens may evoke antibodies cross-reacting with the red blood cells of the host. © 1993 Springer-Verlag.
Anti-erythrocyte autoimmunization in hydatid disease / Girelli, Gabriella; Antonella, Teggi; Perrone, Manuela; Bruno Di, Vico; Giuseppe Maria, Gandolfo; Franco De, Rosa. - In: INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH. - ISSN 0940-5437. - STAMPA. - 23:1-4(1993), pp. 113-115. [10.1007/bf02592293]
Anti-erythrocyte autoimmunization in hydatid disease
GIRELLI, Gabriella;PERRONE, MANUELA;
1993
Abstract
A 73-year-old man with hydatid disease developed autoimmune hemolytic anemia due to IgM cold agglutinin with anti-I specificity. Hemolysis decreased after initiating mebendazole therapy. The cysts notably diminished in size and the red cell autoantibodies disappeared at the end of this treatment. On the basis of these observations, 44 patients with hydatid disease were investigated. One patient showed IgM cold autoantibody with no signs of anemia. In addition, cleavage fragments of C3 were detected on the erythrocyte membranes of 6 patients, following chronic activation of the complement system. We suggest that parasitic antigens may evoke antibodies cross-reacting with the red blood cells of the host. © 1993 Springer-Verlag.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
