The development of neutralizing antibodies (NAbs) to interferon (IFN) is a common phenomenon of IFN beta therapy for relapsing-remitting multiple sclerosis (RRMS) patients. Here we examine the specificity of NAbs developed during therapy for RRMS with recombinant interferon (rIFN) beta-la or rIFN beta-1b, and study the effect of switching from rIFN beta-la to rIFN beta-1b on the incidence and specificity of NAbs. The relative ability to neutralize rIFN beta-Ia and beta-1b was assayed in sera positive for NAbs derived from RRMS patients treated with either rIFN beta-la (N=9) or rIFN beta-lb (N=16), while the incidence and specificity of NAbs to IN beta developed during therapy were studied in 50 RRMS patients who were treated for two years with rIFN beta-la followed by a further year either switching to rIFN beta-1b (N=34) or continuing treatment with rIFN beta-1a (N=16). The results show that all positive sera, independent of the source, may recognize both forms of rIFN beta and that a further year of treatment does not significantly affect the incidence and specificity of the NAbs developed during the first two years of treatment even if treatment is switched to a different type of IFN beta. The data then suggests that it is unlikely that the administration of rIFN beta-1b to anti-rIFN beta-la NAbs-positive patients can overcome the inhibitory effect exerted by the serum antibodies land vice versa), and that a further period of treatment with IFN beta-ib in patients previously treated with rIFN beta-la does not significantly change the pattern of antibody response to IFN beta. (C) 1999 Elsevier Science B.V. All rights reserved.
Further study on the specificity and incidence of neutralizing antibodies to interferon (IFN) in relapsing remitting multiple sclerosis patients treated with IFN beta-1a or IFN beta-1b / Antonelli, Guido; Eleonora, Simeoni; Francesca, Bagnato; Pozzilli, Carlo; Turriziani, Ombretta; Ramon, Tesoro; DI MARCO, Paola; Claudio, Gasperini; Fieschi, Cesare; Ferdinando, Dianzani. - In: JOURNAL OF THE NEUROLOGICAL SCIENCES. - ISSN 0022-510X. - STAMPA. - 168:2(1999), pp. 131-136. [10.1016/s0022-510x(99)00185-9]