Purpose: To correlate the clinical presentation of adult celiac disease with various intestinal fold patterns using MR-enterography. Materials and Methods: Fifty-four consecutive adult celiac patients (34 female, 20 male, 18 to 62 years) were studied by MR-enterography. Two radiologists blinded to the patients' clinical history evaluated in consensus MR studies, classifying the intestinal fold pattern into four categories: (a) no fold abnormalities, (b) isolated loss of folds in the duodenum, (c) jejunization of ileum, and (d) jejuno-ileal fold pattern reversal. Patients presented with the varying clinical forms of Celiac disease, classified as: (i) typical disease, (ii) atypical disease, and (iii) silent form. Results: Twenty-three patients showed no intestinal fold abnormalities; 11 patients had isolated loss of duodenal folds; 9 patients showed jejunization of ileum and 11 had jejuno-ileal fold pattern reversal. 18/23 (78%) patients with MRI normal fold pattern had the silent clinical form of Celiac disease (Sensitivity 78%; specificity 100%; PPV = 1, NPV = 0.78); 9/11 (82%) patients with the isolated loss of duodenal folds had the atypical clinical form (sensitivity 82%; and specificity 100%; PPV = 1; NPV = 0.82). All 20 patients with the jejunization of ileum and jejuno-ileal fold pattern reversal had typical celiac disease (sensitivity and specificity of 100%; PPV and NPV = 1). Conclusion: MR-enterography findings in patients with celiac disease, demonstrates good correlation between MR findings and clinical severity. J. Magn. Reson. Imaging 2012;36:183187. (c) 2012 Wiley Periodicals, Inc.

MR enterography: Relationship between intestinal fold pattern and the clinical presentation of adult celiac disease / Tomei, Ernesto; Diacinti, Daniele; Stagnitti, Andrea; Marini, Mario; Laghi, Andrea; Passariello, Roberto; Richard C., Semelka. - In: JOURNAL OF MAGNETIC RESONANCE IMAGING. - ISSN 1053-1807. - STAMPA. - 36:1(2012), pp. 183-187. [10.1002/jmri.23625]

MR enterography: Relationship between intestinal fold pattern and the clinical presentation of adult celiac disease

TOMEI, Ernesto;DIACINTI, Daniele;STAGNITTI, ANDREA;MARINI, Mario;LAGHI, ANDREA;PASSARIELLO, Roberto;
2012

Abstract

Purpose: To correlate the clinical presentation of adult celiac disease with various intestinal fold patterns using MR-enterography. Materials and Methods: Fifty-four consecutive adult celiac patients (34 female, 20 male, 18 to 62 years) were studied by MR-enterography. Two radiologists blinded to the patients' clinical history evaluated in consensus MR studies, classifying the intestinal fold pattern into four categories: (a) no fold abnormalities, (b) isolated loss of folds in the duodenum, (c) jejunization of ileum, and (d) jejuno-ileal fold pattern reversal. Patients presented with the varying clinical forms of Celiac disease, classified as: (i) typical disease, (ii) atypical disease, and (iii) silent form. Results: Twenty-three patients showed no intestinal fold abnormalities; 11 patients had isolated loss of duodenal folds; 9 patients showed jejunization of ileum and 11 had jejuno-ileal fold pattern reversal. 18/23 (78%) patients with MRI normal fold pattern had the silent clinical form of Celiac disease (Sensitivity 78%; specificity 100%; PPV = 1, NPV = 0.78); 9/11 (82%) patients with the isolated loss of duodenal folds had the atypical clinical form (sensitivity 82%; and specificity 100%; PPV = 1; NPV = 0.82). All 20 patients with the jejunization of ileum and jejuno-ileal fold pattern reversal had typical celiac disease (sensitivity and specificity of 100%; PPV and NPV = 1). Conclusion: MR-enterography findings in patients with celiac disease, demonstrates good correlation between MR findings and clinical severity. J. Magn. Reson. Imaging 2012;36:183187. (c) 2012 Wiley Periodicals, Inc.
2012
adults mri; bowel disease; celiac disease; mr enterography; small intestine
01 Pubblicazione su rivista::01a Articolo in rivista
MR enterography: Relationship between intestinal fold pattern and the clinical presentation of adult celiac disease / Tomei, Ernesto; Diacinti, Daniele; Stagnitti, Andrea; Marini, Mario; Laghi, Andrea; Passariello, Roberto; Richard C., Semelka. - In: JOURNAL OF MAGNETIC RESONANCE IMAGING. - ISSN 1053-1807. - STAMPA. - 36:1(2012), pp. 183-187. [10.1002/jmri.23625]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/436108
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