Although several beta-carboline alkaloids display hallucinogenic properties in humans, their mechanism of action remains unclear. To ascertain their influence on central dopaminergic transmission, in this study we investigated the facilitating effect of low doses of various beta-carbolines on L-DOPA (250 mg/kg)-induced stereotypy in mice. Harmaline (0.075, 0.15 and 0.35 mg/kg) and harmine (0.15, 0.35 and 0.75 mg/kg) powerfully enhanced the degree of stereotypy, whereas 6-methoxy-harmalan, 6-methoxy-harman and harman were far less potent, augmenting stereotypy only at much higher doses (3 mg/kg). 6-Methoxy-tetrahydro-beta-carbolin (6-MeO-THBC) had only a weak effect at the dose of 3 mg/kg and tetrahydro-beta-carbolin (THBC) had no effect up to the dose of 3 mg/kg. The Ca2+-channel blocker nimodipine (2,5 mg/kg) only slightly antagonized harmaline (0.15 mg/kg) facilitation of L-DOPA-induced stereotypy.

Interaction of beta-carbolines with central dopaminergic transmission in mice: structure-activity relationships / Pimpinella, G; Palmery, Maura. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 189:(1995), pp. 121-124. [10.1016/0304-3940(95)11469-D]

Interaction of beta-carbolines with central dopaminergic transmission in mice: structure-activity relationships.

PALMERY, Maura
1995

Abstract

Although several beta-carboline alkaloids display hallucinogenic properties in humans, their mechanism of action remains unclear. To ascertain their influence on central dopaminergic transmission, in this study we investigated the facilitating effect of low doses of various beta-carbolines on L-DOPA (250 mg/kg)-induced stereotypy in mice. Harmaline (0.075, 0.15 and 0.35 mg/kg) and harmine (0.15, 0.35 and 0.75 mg/kg) powerfully enhanced the degree of stereotypy, whereas 6-methoxy-harmalan, 6-methoxy-harman and harman were far less potent, augmenting stereotypy only at much higher doses (3 mg/kg). 6-Methoxy-tetrahydro-beta-carbolin (6-MeO-THBC) had only a weak effect at the dose of 3 mg/kg and tetrahydro-beta-carbolin (THBC) had no effect up to the dose of 3 mg/kg. The Ca2+-channel blocker nimodipine (2,5 mg/kg) only slightly antagonized harmaline (0.15 mg/kg) facilitation of L-DOPA-induced stereotypy.
1995
BETA-CARBOLINES; HARMALINE; DOPAMINE; STEREOTYPED BEHAVIOR
01 Pubblicazione su rivista::01a Articolo in rivista
Interaction of beta-carbolines with central dopaminergic transmission in mice: structure-activity relationships / Pimpinella, G; Palmery, Maura. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 189:(1995), pp. 121-124. [10.1016/0304-3940(95)11469-D]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/435145
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