Clopidogrel is a mainstay in the treatment of patients with acute coronary syndromes or those receiving endovascular prostheses. However, its efficacy has been challenged in the recent past by studies suggesting variable individual responsiveness and by new, more potent competitors, such as prasugrel and ticagrelor. But what is the actual body of evidence in support of clopidogrel? Is there any dark side of the moon? What is the role of prasugrel, which has already been approved in Europe and in the United States? And what will be the future role of ticagrelor, when approved for routine clinical practice? We hereby concisely summarize the scope of this clinical choice, providing arguments in favor and against each of the three antiplatelet agents: clopidogrel, prasugrel, and ticagrelor.

Alternatives to clopidogrel for acute coronary syndromes: Prasugrel or ticagrelor? / BIONDI ZOCCAI, Giuseppe; M., Lotrionte; F., Gaita. - In: WORLD JOURNAL OF CARDIOLOGY. - ISSN 1949-8462. - 2:6(2010), p. 131. [10.4330/wjc.v2.i6.131]

Alternatives to clopidogrel for acute coronary syndromes: Prasugrel or ticagrelor?

BIONDI ZOCCAI, GIUSEPPE;
2010

Abstract

Clopidogrel is a mainstay in the treatment of patients with acute coronary syndromes or those receiving endovascular prostheses. However, its efficacy has been challenged in the recent past by studies suggesting variable individual responsiveness and by new, more potent competitors, such as prasugrel and ticagrelor. But what is the actual body of evidence in support of clopidogrel? Is there any dark side of the moon? What is the role of prasugrel, which has already been approved in Europe and in the United States? And what will be the future role of ticagrelor, when approved for routine clinical practice? We hereby concisely summarize the scope of this clinical choice, providing arguments in favor and against each of the three antiplatelet agents: clopidogrel, prasugrel, and ticagrelor.
2010
01 Pubblicazione su rivista::01a Articolo in rivista
Alternatives to clopidogrel for acute coronary syndromes: Prasugrel or ticagrelor? / BIONDI ZOCCAI, Giuseppe; M., Lotrionte; F., Gaita. - In: WORLD JOURNAL OF CARDIOLOGY. - ISSN 1949-8462. - 2:6(2010), p. 131. [10.4330/wjc.v2.i6.131]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/434390
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