Background: Because of the recently published results of the MAGIC study there is confusion as to whether administration of granulocyte-colony stimulating factor (G-CSF) after acute myocardial infarction (MI) should be regarded as a potentially harmful treatment. This metaanalysis of appropriate clinical studies is intended to show the impact of G-CSF given after MI on aggravated incidence of coronary re-stenosis or progression of coronary lesions. Methods: We used a fixed effects model based on the Mantel-Haenszel method to combine results from the different trials. These studies provided the basis for the current analysis comprising 106 patients of whom 62 were subjected to G-CSF treatment. Results: Minimum lumen diameter (MLD) measured immediately after percutaneous coronary intervention (PCI) was similar in both groups with a diameter stenosis of 12.3% (SD 9.5%) in the G-CSF group and 10.3% (8.5%) in the control group (p = 0.32). At follow-up, both MLD and percentage stenosis were not different between G-CSF-treated and control patients. Subsequently, averaged late lumen loss revealed similar results and no differences between groups (p = 0.11), and neither stent thrombosis nor re-infarction in either group. Conclusions: The current meta-analysis of clinical reports fails to justify an elevated risk for coronary restenosis after PCI in acute MI or adverse events following G-CSF in the setting of MI when used after state of the art treatment in carefully conducted clinical protocols.

Cardiovascular events and re-stenosis following administration of G-CSF in acute myocardial infarction: Systematic review and meta-analysis / H., Ince; M., Valgimigli; M., Petzsch; J. S., De Lezo; F., Kuethe; S., Dunkelmann; BIONDI ZOCCAI, Giuseppe; C. A., Nienaber. - In: HEART. - ISSN 1355-6037. - 94:5(2008), pp. 610-616. [10.1136/hrt.2006.111385]

Cardiovascular events and re-stenosis following administration of G-CSF in acute myocardial infarction: Systematic review and meta-analysis

BIONDI ZOCCAI, GIUSEPPE;
2008

Abstract

Background: Because of the recently published results of the MAGIC study there is confusion as to whether administration of granulocyte-colony stimulating factor (G-CSF) after acute myocardial infarction (MI) should be regarded as a potentially harmful treatment. This metaanalysis of appropriate clinical studies is intended to show the impact of G-CSF given after MI on aggravated incidence of coronary re-stenosis or progression of coronary lesions. Methods: We used a fixed effects model based on the Mantel-Haenszel method to combine results from the different trials. These studies provided the basis for the current analysis comprising 106 patients of whom 62 were subjected to G-CSF treatment. Results: Minimum lumen diameter (MLD) measured immediately after percutaneous coronary intervention (PCI) was similar in both groups with a diameter stenosis of 12.3% (SD 9.5%) in the G-CSF group and 10.3% (8.5%) in the control group (p = 0.32). At follow-up, both MLD and percentage stenosis were not different between G-CSF-treated and control patients. Subsequently, averaged late lumen loss revealed similar results and no differences between groups (p = 0.11), and neither stent thrombosis nor re-infarction in either group. Conclusions: The current meta-analysis of clinical reports fails to justify an elevated risk for coronary restenosis after PCI in acute MI or adverse events following G-CSF in the setting of MI when used after state of the art treatment in carefully conducted clinical protocols.
2008
01 Pubblicazione su rivista::01a Articolo in rivista
Cardiovascular events and re-stenosis following administration of G-CSF in acute myocardial infarction: Systematic review and meta-analysis / H., Ince; M., Valgimigli; M., Petzsch; J. S., De Lezo; F., Kuethe; S., Dunkelmann; BIONDI ZOCCAI, Giuseppe; C. A., Nienaber. - In: HEART. - ISSN 1355-6037. - 94:5(2008), pp. 610-616. [10.1136/hrt.2006.111385]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/434225
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