This review explores the epidemiological evidence for the relationship between depression and cardiovascular disease from a mechanistic standpoint. It is important to examine the biological, behavioral and social mechanisms to improve outcomes for depressed cardiac patients. A number of plausible biobehavioral mechanisms linking depression and cardiovascular disease have been identified. Tricyclic antidepressants have various effects on the cardiovascular system, while selective serotonin reuptake inhibitors are not associated with adverse cardiac effects and should, therefore, be the preferred choice for the treatment of most patients with comorbid depression and cardiovascular disease. © 2009 Expert Reviews Ltd.
Depression and the cardiovascular system: Increasing evidence of a link and therapeutic implications / Giuseppe, Marano; Desiree, Harnic; Marzia, Lotrionte; BIONDI ZOCCAI, Giuseppe; Antonio, Abbate; Enrico, Romagnoli; Marianna, Mazza. - In: EXPERT REVIEW OF CARDIOVASCULAR THERAPY. - ISSN 1477-9072. - 7:9(2009), pp. 1123-1147. [10.1586/erc.09.78]
Depression and the cardiovascular system: Increasing evidence of a link and therapeutic implications
BIONDI ZOCCAI, GIUSEPPE;
2009
Abstract
This review explores the epidemiological evidence for the relationship between depression and cardiovascular disease from a mechanistic standpoint. It is important to examine the biological, behavioral and social mechanisms to improve outcomes for depressed cardiac patients. A number of plausible biobehavioral mechanisms linking depression and cardiovascular disease have been identified. Tricyclic antidepressants have various effects on the cardiovascular system, while selective serotonin reuptake inhibitors are not associated with adverse cardiac effects and should, therefore, be the preferred choice for the treatment of most patients with comorbid depression and cardiovascular disease. © 2009 Expert Reviews Ltd.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
