After acute coronary syndromes,the beneficial effect of aspirin plus clopidogrel (A + C) or aspirin plus dose-adjusted warfarin (A + W) compared with aspirin alone is well established. However, these regimens were never compared. To compare the risk-benefit profile of A + C versus A + W after acute coronary syndromes, major medical databases for randomized controlled trials comparing 1 of these combined approaches versus aspirin alone after an acute coronary. syndrome (updated June 2006) were searched. Evaluated end points were major adverse events [MAEs: all-cause death, acute myocardial infarction [AMI], thromboembolic stroke, major bleeds, and overall risk of stroke [hemorrhagic or ischemic]). Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for (1) A + W versus aspirin alone, (2) A + C versus aspirin alone, and (3) A + W versus A + C using adjusted indirect meta-analysis. Thirteen studies were included, totaling 69,741 patients. Ten compared A + W versus aspirin alone and 3 compared A + C versus aspirin alone. Each combined approach yielded a significantly lower risk of MAEs, albeit an increased risk of major bleeds, compared with aspirin alone. No significant difference was found for A + W versus A + C for risk of overall MAEs, death, or AMI. However, A + W versus A + C was associated with a significantly lower risk of thromboembolic stroke (OR 0.53, 95% CI 0.31 to 0.88, number needed to treat 60) and all types of stroke (OR 0.58, 95% CI 0.35 to 0.94, p = 0.038), but also with increased risk of major bleeds (OR 1.9, 95% CI 1.2 to 2.8, number needed to harm 300). In conclusion, after an acute coronary syndrome, A + W and A + C are comparable in the prevention of MAEs, death, and AMI compared with aspirin alone. Allocating 100 patients to A + W (at international normalized ratio 2 to 3) with respect to A + C could prevent 17 thromboembolic strokes while causing 3 major bleeds. (c) 2007 Elsevier Inc. All rights reserved.

Adjusted indirect meta-analysis of Aspirin plus Warfarin at international normalized ratios 2 to 3 versus Aspirin plus Clopidogrel after acute coronary syndromes / Luca, Testa; BIONDI ZOCCAI, Giuseppe; Italo, Porto; Graziana, Trotta; Pierfrancesco, Agostoni; Felicita, Andreotti; Filippo, Crea. - In: THE AMERICAN JOURNAL OF CARDIOLOGY. - ISSN 0002-9149. - STAMPA. - 99:12(2007), pp. 1637-1642. [10.1016/j.amjcard.2007.01.052]

Adjusted indirect meta-analysis of Aspirin plus Warfarin at international normalized ratios 2 to 3 versus Aspirin plus Clopidogrel after acute coronary syndromes

BIONDI ZOCCAI, GIUSEPPE;
2007

Abstract

After acute coronary syndromes,the beneficial effect of aspirin plus clopidogrel (A + C) or aspirin plus dose-adjusted warfarin (A + W) compared with aspirin alone is well established. However, these regimens were never compared. To compare the risk-benefit profile of A + C versus A + W after acute coronary syndromes, major medical databases for randomized controlled trials comparing 1 of these combined approaches versus aspirin alone after an acute coronary. syndrome (updated June 2006) were searched. Evaluated end points were major adverse events [MAEs: all-cause death, acute myocardial infarction [AMI], thromboembolic stroke, major bleeds, and overall risk of stroke [hemorrhagic or ischemic]). Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for (1) A + W versus aspirin alone, (2) A + C versus aspirin alone, and (3) A + W versus A + C using adjusted indirect meta-analysis. Thirteen studies were included, totaling 69,741 patients. Ten compared A + W versus aspirin alone and 3 compared A + C versus aspirin alone. Each combined approach yielded a significantly lower risk of MAEs, albeit an increased risk of major bleeds, compared with aspirin alone. No significant difference was found for A + W versus A + C for risk of overall MAEs, death, or AMI. However, A + W versus A + C was associated with a significantly lower risk of thromboembolic stroke (OR 0.53, 95% CI 0.31 to 0.88, number needed to treat 60) and all types of stroke (OR 0.58, 95% CI 0.35 to 0.94, p = 0.038), but also with increased risk of major bleeds (OR 1.9, 95% CI 1.2 to 2.8, number needed to harm 300). In conclusion, after an acute coronary syndrome, A + W and A + C are comparable in the prevention of MAEs, death, and AMI compared with aspirin alone. Allocating 100 patients to A + W (at international normalized ratio 2 to 3) with respect to A + C could prevent 17 thromboembolic strokes while causing 3 major bleeds. (c) 2007 Elsevier Inc. All rights reserved.
2007
01 Pubblicazione su rivista::01a Articolo in rivista
Adjusted indirect meta-analysis of Aspirin plus Warfarin at international normalized ratios 2 to 3 versus Aspirin plus Clopidogrel after acute coronary syndromes / Luca, Testa; BIONDI ZOCCAI, Giuseppe; Italo, Porto; Graziana, Trotta; Pierfrancesco, Agostoni; Felicita, Andreotti; Filippo, Crea. - In: THE AMERICAN JOURNAL OF CARDIOLOGY. - ISSN 0002-9149. - STAMPA. - 99:12(2007), pp. 1637-1642. [10.1016/j.amjcard.2007.01.052]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/433992
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 47
  • ???jsp.display-item.citation.isi??? 43
social impact