Regional neurotransmitter changes after acute and chronic electroconvulsive shock (ECS) were studied using the technique of repeated microdialysis. Microdialysis was carried out on alternate sides of the brains of anaesthetised rats before and during the first and the eighth ECS or sham (control) treatments. Extracellular fluid release of monoamines and their metabolites was measured in the frontal cortex, striatum and nucleus accumbens using HPLC with electrochemical detection. The first ECS produced selective regional responses, shown by increased concentrations of noradrenaline (NA) and dopamine (DA) in frontal cortex, by unchanged DA content in striatum, and by a small rise in NA and a fall in DA concentrations in nucleus accumbens. Concentrations of metabolites increased after ECS in all regions studied, and for homovanillic acid and dihydroxyphenylacetic acid, the temporal pattern of these changes did not resemble that of DA. Comparison of neurotransmitter responses as per cent of baseline release after the first and eighth ECS treatments showed they were identical. Basal release of monoamines and metabolites before the first ECS or sham treatment was similar in all regions studied. Prior to the eighth treatment, basal release of NA in the frontal cortex and DA in the striatum was elevated in the ECS-treated animals, while basal release of NA in the nucleus accumbens was reduced in both ECS-and sham-treated animals. These data suggest that acute and chronic ECS have different and region-specific effects on neurotransmitter release, although the overall pattern of these responses is not changed by chronic treatment. The catecholamine-releasing actions of ECS, and the changes in basal release of neurotransmitters seen after chronic treatment may contribute to its therapeutic effects. © 1990 Springer-Verlag.
REGIONAL NEUROTRANSMITTER RESPONSES AFTER ACUTE AND CHRONIC ELECTROCONVULSIVE SHOCK / Paul, Glue; M. J., Costello; Agu, Pert; Mele, Andrea; David J., Nutt. - In: PSYCHOPHARMACOLOGY. - ISSN 0033-3158. - STAMPA. - 100:1(1990), pp. 60-65. [10.1007/bf02245791]
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|Titolo:||REGIONAL NEUROTRANSMITTER RESPONSES AFTER ACUTE AND CHRONIC ELECTROCONVULSIVE SHOCK|
|Data di pubblicazione:||1990|
|Citazione:||REGIONAL NEUROTRANSMITTER RESPONSES AFTER ACUTE AND CHRONIC ELECTROCONVULSIVE SHOCK / Paul, Glue; M. J., Costello; Agu, Pert; Mele, Andrea; David J., Nutt. - In: PSYCHOPHARMACOLOGY. - ISSN 0033-3158. - STAMPA. - 100:1(1990), pp. 60-65. [10.1007/bf02245791]|
|Appartiene alla tipologia:||01a Articolo in rivista|