The interaction between Na-DNA and divalent metal cations (Mg2+, Mn2+, Co2+ and Ni2+) has been investigated by 23Na NMR relaxation. The experimental data have been interpreted in terms of Manning's counterion condensation theory and a two-site exchange for the sodium ions. The experiments showed that Mn2+ affects the polyion surface atmosphere in a different way from the other metal ions. This behaviour may be due to sugar puckering transition of the DNA induced by Mn2+.
Interaction of divalent metal ions with DNA investigated by 23Na NMR relaxation / F. C., Marincola; Mariano, Casu; Giuseppe, Saba; Manetti, Cesare; Adolfo, Lai. - In: PHYSICAL CHEMISTRY CHEMICAL PHYSICS. - ISSN 1463-9076. - STAMPA. - 2:10(2000), pp. 2425-2428. [10.1039/b000433m]
Interaction of divalent metal ions with DNA investigated by 23Na NMR relaxation
MANETTI, Cesare;
2000
Abstract
The interaction between Na-DNA and divalent metal cations (Mg2+, Mn2+, Co2+ and Ni2+) has been investigated by 23Na NMR relaxation. The experimental data have been interpreted in terms of Manning's counterion condensation theory and a two-site exchange for the sodium ions. The experiments showed that Mn2+ affects the polyion surface atmosphere in a different way from the other metal ions. This behaviour may be due to sugar puckering transition of the DNA induced by Mn2+.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
