Oral and intravenous pharmacokinetic profiles of doxofylline in patients with chronic bronchitis

Bologna, E.; Lagana', Aldo; Terracino, D.; Bolignari, P.; Biffignandi, P.

Serum doxofylline concentrations were evaluated after solid-phase extraction byhigh-performance liquid chromatography following administration of 100 mg doxofylline given as a single intravenous dose over 10 min or 400 mg doxofylline given orally twice daily for 5 days in six and eight non-smoking, fasting, chronic bronchitic patients, respectively. Doxofylline possessed a very short distribution phase following intravenous administration, with a sustained elimination phase (half-life 1.83 ± 0.37 h). After oral administration, the peak serum doxofylline concentration was 15.21 ± 1.73 μg/ml and the mean elimination half-life was 7.01 ± 0.80 h; there was a large inter-subject variability. No side-effects were experienced by the patients during the study.

Oral and intravenous pharmacokinetic profiles of doxofylline in patients with chronic bronchitis / E., Bologna; Lagana', Aldo; D., Terracino; P., Bolignari; P., Biffignandi. - In: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH. - ISSN 0300-0605. - STAMPA. - 18:4(1990), pp. 282-288.

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Titolo:	Oral and intravenous pharmacokinetic profiles of doxofylline in patients with chronic bronchitis
Autori:	E. Bologna LAGANA', Aldo D. Terracino P. Bolignari P. Biffignandi mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1990
Rivista:	JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Citazione:	Oral and intravenous pharmacokinetic profiles of doxofylline in patients with chronic bronchitis / E., Bologna; Lagana', Aldo; D., Terracino; P., Bolignari; P., Biffignandi. - In: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH. - ISSN 0300-0605. - STAMPA. - 18:4(1990), pp. 282-288.
Handle:	http://hdl.handle.net/11573/431873
Appartiene alla tipologia:	01a Articolo in rivista

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