Skin extracts of South American hylid frogs of the subfamily Phyllomedusinae contain dermorphins and deltorphins, opioid heptapeptides highly selective for either μ or δ receptors. In all these peptides, a D-amino acid is present in the second position. The structure of the precursors for Ala-deltorphins was recently deduced from cloned cDNAs derived from skin of Phyllomedusa bicolor (Richter et al. (1990) Proc. Natl. Acad. Sci. USA 87, 4836-4839). From the amino acid sequence of these precursors, the existence of three peptides related to dermorphin could be predicted. From methanol extracts of skin of Ph. bicolor we have isolated two of these peptides, [Lys7]dermorphin-OH and [Trp4,Asn7]dermorphin-OH. The biological activity of these new dermorphins and their amidated couterparts is presented.

Identification and characterization of two dermorphins from skin extracts of the Amazonian frog Phyllomedusa bicolor / Mignogna, Giuseppina; Cinzia, Severini; Simmaco, Maurizio; Negri, Lucia; Giuliana Falconieri, Erspamer; Günther, Kreil; Barra, Donatella. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 302:2(1992), pp. 151-154. [10.1016/0014-5793(92)80427-i]

Identification and characterization of two dermorphins from skin extracts of the Amazonian frog Phyllomedusa bicolor

MIGNOGNA, Giuseppina;SIMMACO, Maurizio;NEGRI, Lucia;BARRA, Donatella
1992

Abstract

Skin extracts of South American hylid frogs of the subfamily Phyllomedusinae contain dermorphins and deltorphins, opioid heptapeptides highly selective for either μ or δ receptors. In all these peptides, a D-amino acid is present in the second position. The structure of the precursors for Ala-deltorphins was recently deduced from cloned cDNAs derived from skin of Phyllomedusa bicolor (Richter et al. (1990) Proc. Natl. Acad. Sci. USA 87, 4836-4839). From the amino acid sequence of these precursors, the existence of three peptides related to dermorphin could be predicted. From methanol extracts of skin of Ph. bicolor we have isolated two of these peptides, [Lys7]dermorphin-OH and [Trp4,Asn7]dermorphin-OH. The biological activity of these new dermorphins and their amidated couterparts is presented.
1992
amphibian skin; deltorphin; dermorphin; opioid peptide
01 Pubblicazione su rivista::01a Articolo in rivista
Identification and characterization of two dermorphins from skin extracts of the Amazonian frog Phyllomedusa bicolor / Mignogna, Giuseppina; Cinzia, Severini; Simmaco, Maurizio; Negri, Lucia; Giuliana Falconieri, Erspamer; Günther, Kreil; Barra, Donatella. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 302:2(1992), pp. 151-154. [10.1016/0014-5793(92)80427-i]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/42987
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