Recombinant GH therapy is normally administered to GH-deficient children in order to achieve a satisfactory height - the main target during childhood and adolescence. However, the role of GH does not end once final height has been reached, but continues during the so-called transition period. In this phase of life, the body undergoes several changes, both physical and psychological, that culminate in adulthood. During this period, GH has a part in numerous metabolic functions. These include the lipid profile, where it increases HDL and reduces LDL, with the global effect of cardiovascular protection. It also has important effects on body composition (improved muscle strength and lean body mass and reduced body fat), the achievement of proper peak bone density, and gonad maturation. Retesting during the transition period, involving measurement of IGF-I plus a provocative test (insulin tolerance test or GHRH + arginine test), is thus necessary to establish any persistent GH deficiency requiring additional replacement therapy. The close cooperation of the medical professionals involved in the patient's transition from a pediatric to an adult endocrinologist is essential. The aim of this review is to point out the main aspects of GH treatment on body composition, metabolic and gonad functions in the transition period. (J. Endocrinol. Invest. 34: 709-715, 2011) (C) 2011, Editrice Kurtis

Growth hormone deficiency in the transition period: Body composition and gonad function / Balercia, G.; Giovannini, L.; Paggi, F.; Spaziani, M.; Tahani, N.; Boscaro, M.; Lenzi, Andrea; Radicioni, Antonio. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - STAMPA. - 34:9(2011), pp. 709-715. [10.3275/7804]

Growth hormone deficiency in the transition period: Body composition and gonad function

M. Spaziani;N. Tahani;LENZI, Andrea;RADICIONI, Antonio
2011

Abstract

Recombinant GH therapy is normally administered to GH-deficient children in order to achieve a satisfactory height - the main target during childhood and adolescence. However, the role of GH does not end once final height has been reached, but continues during the so-called transition period. In this phase of life, the body undergoes several changes, both physical and psychological, that culminate in adulthood. During this period, GH has a part in numerous metabolic functions. These include the lipid profile, where it increases HDL and reduces LDL, with the global effect of cardiovascular protection. It also has important effects on body composition (improved muscle strength and lean body mass and reduced body fat), the achievement of proper peak bone density, and gonad maturation. Retesting during the transition period, involving measurement of IGF-I plus a provocative test (insulin tolerance test or GHRH + arginine test), is thus necessary to establish any persistent GH deficiency requiring additional replacement therapy. The close cooperation of the medical professionals involved in the patient's transition from a pediatric to an adult endocrinologist is essential. The aim of this review is to point out the main aspects of GH treatment on body composition, metabolic and gonad functions in the transition period. (J. Endocrinol. Invest. 34: 709-715, 2011) (C) 2011, Editrice Kurtis
2011
body composition; gh deficiency; gonads; transition
01 Pubblicazione su rivista::01a Articolo in rivista
Growth hormone deficiency in the transition period: Body composition and gonad function / Balercia, G.; Giovannini, L.; Paggi, F.; Spaziani, M.; Tahani, N.; Boscaro, M.; Lenzi, Andrea; Radicioni, Antonio. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - STAMPA. - 34:9(2011), pp. 709-715. [10.3275/7804]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/429118
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