A series of naftifine analogues having the biphenyl instead of the naphthyl moiety have been synthesized in a search devoted to study bioanalogues of clinically efficacious antifungal agents. The new derivatives were tested against Candida albicans by the direct contact method. They were also assayed against Gram-positive and: Gram-negative bacteria and against some isolates of plant pathogenic fungi. Derivatives 8a, 8c, and 9a were found to be active against Candida albicans, derivative 5a was active against E. coli, a very resistant species to antimycotic agents, and derivatives 8a and 8b inhibited the plant pathogenic Rhizoctonia solani.
Biphenyl analogues of naftifine: Synthesis and antifungal activities / Porretta, Giulio Cesare; Fioravanti, Rossella; Biava, Mariangela; Artico, M.; Villa, A.; Simonetti, N.. - In: ARCHIV DER PHARMAZIE. - ISSN 0365-6233. - STAMPA. - 328:(1995), pp. 667-672. [10.1002/ardp.19953280907]
Biphenyl analogues of naftifine: Synthesis and antifungal activities
PORRETTA, Giulio Cesare;FIORAVANTI, Rossella;BIAVA, Mariangela;M. Artico;
1995
Abstract
A series of naftifine analogues having the biphenyl instead of the naphthyl moiety have been synthesized in a search devoted to study bioanalogues of clinically efficacious antifungal agents. The new derivatives were tested against Candida albicans by the direct contact method. They were also assayed against Gram-positive and: Gram-negative bacteria and against some isolates of plant pathogenic fungi. Derivatives 8a, 8c, and 9a were found to be active against Candida albicans, derivative 5a was active against E. coli, a very resistant species to antimycotic agents, and derivatives 8a and 8b inhibited the plant pathogenic Rhizoctonia solani.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.