Objectives: increased incidence of acute coronary events, high rate of abnormal surrogate markers of atherosclerosis and increased amount of coronary calcium have been described in HIV infected population. To expand knowledge on coronary artery disease (CAD) in HIV patients, cardiac CT scan was performed in asymptomatic subjects with low cardiovascular (CV) risk. Methods: A cross-sectional study using dual-source CT (MDCT) coronary angiography. was conducted in HIV-infected subjects with the following characteristics: Framingham Risk Score (FRS) <= 10, absence of metabolic syndrome, negative echocardiographic and ECG stress-test. A luminal narrowing exceeding 50% was defined as a clinically significant coronary stenosis. Calcium score was quantified using the Agatston Calcium Score method. Results: Fifty-five subjects were enrolled. Significant coronary stenoses, requiring coronary angiography, were found in 16/55 (29.1%). At multivariate analysis older age was the only variable independently associated with the presence of significant luminal narrowing (p = 0.011). Conclusions: MDCT showed an unexpected, age-associated high rate of significant coronary stenosis in asymptomatic HIV positive subjects with low CV risk. These findings suggest that aggressive screening programs for coronary artery disease may be appropriate in this population; further studies are recommended to assess the appropriateness of MDCT for this purpose. (C) 2011 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

Significant coronary stenosis detected by coronary computed angiography in asymptomatic HIV infected subjects / D'Ettorre, Gabriella; Francone, Marco; Mancone, Massimo; Ceccarelli, Giancarlo; Ascarelli, Adriano; Vullo, Francesco; Silvia, Baroncelli; M., Clementina Galluzzo; Catalano, Carlo; Strano, Stefano; Fedele, Francesco; Mastroianni, Claudio Maria; Lucia, Palmisano; Vullo, Vincenzo. - In: JOURNAL OF INFECTION. - ISSN 0163-4453. - STAMPA. - 64:1(2012), pp. 82-88. [10.1016/j.jinf.2011.09.007]

Significant coronary stenosis detected by coronary computed angiography in asymptomatic HIV infected subjects

D'ETTORRE, Gabriella;FRANCONE, MARCO;MANCONE, Massimo;CECCARELLI, GIANCARLO;ASCARELLI, ADRIANO;VULLO, FRANCESCO;CATALANO, Carlo;STRANO, Stefano;FEDELE, Francesco;MASTROIANNI, Claudio Maria;VULLO, Vincenzo
2012

Abstract

Objectives: increased incidence of acute coronary events, high rate of abnormal surrogate markers of atherosclerosis and increased amount of coronary calcium have been described in HIV infected population. To expand knowledge on coronary artery disease (CAD) in HIV patients, cardiac CT scan was performed in asymptomatic subjects with low cardiovascular (CV) risk. Methods: A cross-sectional study using dual-source CT (MDCT) coronary angiography. was conducted in HIV-infected subjects with the following characteristics: Framingham Risk Score (FRS) <= 10, absence of metabolic syndrome, negative echocardiographic and ECG stress-test. A luminal narrowing exceeding 50% was defined as a clinically significant coronary stenosis. Calcium score was quantified using the Agatston Calcium Score method. Results: Fifty-five subjects were enrolled. Significant coronary stenoses, requiring coronary angiography, were found in 16/55 (29.1%). At multivariate analysis older age was the only variable independently associated with the presence of significant luminal narrowing (p = 0.011). Conclusions: MDCT showed an unexpected, age-associated high rate of significant coronary stenosis in asymptomatic HIV positive subjects with low CV risk. These findings suggest that aggressive screening programs for coronary artery disease may be appropriate in this population; further studies are recommended to assess the appropriateness of MDCT for this purpose. (C) 2011 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
2012
hiv; heart; ct scan
01 Pubblicazione su rivista::01a Articolo in rivista
Significant coronary stenosis detected by coronary computed angiography in asymptomatic HIV infected subjects / D'Ettorre, Gabriella; Francone, Marco; Mancone, Massimo; Ceccarelli, Giancarlo; Ascarelli, Adriano; Vullo, Francesco; Silvia, Baroncelli; M., Clementina Galluzzo; Catalano, Carlo; Strano, Stefano; Fedele, Francesco; Mastroianni, Claudio Maria; Lucia, Palmisano; Vullo, Vincenzo. - In: JOURNAL OF INFECTION. - ISSN 0163-4453. - STAMPA. - 64:1(2012), pp. 82-88. [10.1016/j.jinf.2011.09.007]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/423575
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