In this study we have sought possible differences in the initial and short-term hypotensive effects of nifedipine in hypertensive patients in relation to their renin profile. A highly significant decrease in BP was observed in low-renin and normal-renin hypertensive patients, while a less pronounced fall was found in high-renin hypertensives. Furthermore, 55% of low-renin hypertensives had their diastolic BP normalized after 1 week of therapy, whereas the same result was obtained only in 33% of high-renin hypertensives. These data indicate that nifedipine can be used as first-choice drug in low-renin hypertension, although pre-treatment renin profile might not be employed as a sure predicting index of a short-term efficacy of this drug.
SHORT-TERM EFFICACY OF NIFEDIPINE IN ESSENTIAL AND RENOVASCULAR HYPERTENSION / P., Madeddu; Rubattu, Speranza Donatella; M. A., Spanu; F. M., Pala; P., Dessi Fulgheri; N., Glorioso; A., Rappelli. - In: AMERICAN JOURNAL OF NEPHROLOGY. - ISSN 0250-8095. - 6:1(1986), pp. 105-107. [10.1159/000167230]
SHORT-TERM EFFICACY OF NIFEDIPINE IN ESSENTIAL AND RENOVASCULAR HYPERTENSION
RUBATTU, Speranza Donatella;
1986
Abstract
In this study we have sought possible differences in the initial and short-term hypotensive effects of nifedipine in hypertensive patients in relation to their renin profile. A highly significant decrease in BP was observed in low-renin and normal-renin hypertensive patients, while a less pronounced fall was found in high-renin hypertensives. Furthermore, 55% of low-renin hypertensives had their diastolic BP normalized after 1 week of therapy, whereas the same result was obtained only in 33% of high-renin hypertensives. These data indicate that nifedipine can be used as first-choice drug in low-renin hypertension, although pre-treatment renin profile might not be employed as a sure predicting index of a short-term efficacy of this drug.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
