A large set of ground-based multi-frequency microwave radiometric simulations and measurements during different precipitation regimes are analysed. Simulations are performed for a set of frequencies from 22 to 60 GHz, representing the channels currently available on an operational ground-based radiometric system. Results are illustrated in terms of comparisons between measurements and model data in order to show that the observed radiometric signatures can be attributed to rainfall scattering and absorption. An inversion algorithm has been developed, basing on the simulated data, to retrieve rain rate from passive radiometric observations. As a validation of the approach, we have analyzed radiometric measurements during rain events occurred in Boulder, Colorado, and at the Atmospheric Radiation Measurement (ARM) Program’s Southern Great Plains (SGP) site in Lamont, Oklahoma, USA, comparing rain rate estimates with available simultaneous rain gauge data.