Purpose. The aim of our study was to investigate the role of fetal magnetic resonance imaging (MRI) as a complement to ultrasound (US) in the evaluation of cleft lip and palate (CLP), whether isolated or in association with syndromic conditions. Materials and methods. We enrolled 24 pregnant women (27 fetuses) (mean gestational age 23.7 weeks) with a level-two US diagnosis of cleft lip (CL) or CLP with or without associated central nervous system (CNS) or facial-bone anomalies. All individuals underwent a fetal MRI examination to study the facial skeleton, CNS and fetal body. For each fetus, the main anatomical facial landmarks and biometric parameters [anteroposterior diameter (APD), biparietal diameter (BPD), inferior facial angle (IFA), frontomaxillary angle (FMA), bi-orbital diameter (BOD), intraorbital diameter (IOD)] were measured. Results. Twenty-five of 27 fetuses had a US diagnosis of CL or CLP. MRI confirmed the diagnosis in 16/25 fetuses and added information about the extent of the cleft and the degree of involvement of the anterior and posterior palate in 8/25 fetuses. MRI ruled out the diagnosis in 1/25 fetuses and identified an alteration of the parameters IFA, FMA and IOD in 6/24 fetuses. Conclusions. In the study of CLP fetal, MRI is able to define the degree of involvement of the posterior palate and the lateral extent of the cleft with higher diagnostic accuracy than US. Furthermore, MRI provides a complete study of the fetal head and biometric development of the facial bones, thus enabling early detection of potential syndromic conditions.

Fetal MRI as a complement to US in the evaluation of cleft lip and palate / Manganaro, Lucia; Tomei, A.; Fierro, F.; Di Maurizio, M.; Sollazzo, P.; Sergi, M. E.; Vinci, V.; Bernardo, S.; Irimia, D.; Cascone, Piero; Marini, Mario. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - 116:7(2011), pp. 1134-1148. [10.1007/s11547-011-0683-8]

Fetal MRI as a complement to US in the evaluation of cleft lip and palate

MANGANARO, Lucia;S. Bernardo;CASCONE, PIERO;MARINI, Mario
2011

Abstract

Purpose. The aim of our study was to investigate the role of fetal magnetic resonance imaging (MRI) as a complement to ultrasound (US) in the evaluation of cleft lip and palate (CLP), whether isolated or in association with syndromic conditions. Materials and methods. We enrolled 24 pregnant women (27 fetuses) (mean gestational age 23.7 weeks) with a level-two US diagnosis of cleft lip (CL) or CLP with or without associated central nervous system (CNS) or facial-bone anomalies. All individuals underwent a fetal MRI examination to study the facial skeleton, CNS and fetal body. For each fetus, the main anatomical facial landmarks and biometric parameters [anteroposterior diameter (APD), biparietal diameter (BPD), inferior facial angle (IFA), frontomaxillary angle (FMA), bi-orbital diameter (BOD), intraorbital diameter (IOD)] were measured. Results. Twenty-five of 27 fetuses had a US diagnosis of CL or CLP. MRI confirmed the diagnosis in 16/25 fetuses and added information about the extent of the cleft and the degree of involvement of the anterior and posterior palate in 8/25 fetuses. MRI ruled out the diagnosis in 1/25 fetuses and identified an alteration of the parameters IFA, FMA and IOD in 6/24 fetuses. Conclusions. In the study of CLP fetal, MRI is able to define the degree of involvement of the posterior palate and the lateral extent of the cleft with higher diagnostic accuracy than US. Furthermore, MRI provides a complete study of the fetal head and biometric development of the facial bones, thus enabling early detection of potential syndromic conditions.
2011
cleft lip and palate; facial cleft; fetal mri; prenatal diagnosis
01 Pubblicazione su rivista::01a Articolo in rivista
Fetal MRI as a complement to US in the evaluation of cleft lip and palate / Manganaro, Lucia; Tomei, A.; Fierro, F.; Di Maurizio, M.; Sollazzo, P.; Sergi, M. E.; Vinci, V.; Bernardo, S.; Irimia, D.; Cascone, Piero; Marini, Mario. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - 116:7(2011), pp. 1134-1148. [10.1007/s11547-011-0683-8]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/422231
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 45
  • ???jsp.display-item.citation.isi??? 35
social impact