We report the case of a 42-year-old woman with inflammatory cancer of the right breast treated with neoadjuvant chemotherapy, surgery, additional chemotherapy, and consolidative radiotherapy (RT), that has metastatized to the chest wall and presented a resumption of disease on the contralateral breast. Magnetic Resonance (MR), performed after the second phase's fourth round of additional chemotherapy, showed a modest reduction of scar metastases on the right and a contralateral anomalous skin thickening with high signal intensity in T2 weighted images (WI) with multiple mass-like enhancements located in a wide area of the central region at the union of higher quadrants. These findings were suggestive for resumption of contralateral disease; the biopsy confirmed an inflammatory breast cancer (IBC) infiltrating lobular type with high mitotic rate. A retrospective evaluation of the previous MR exam, performed 5 months before, was conducted: on the left side only a modest skin thickening was found as an early sign. A careful review of the literature has confirmed that skin thickening, increased density and clinical signs of inflammation are the most common findings in inflammatory cancer. We report the case of a patient affected by IBC whose unique early sign of resumption on the contralateral breast was skin thickening.

Skin thickening as unique pathologic sign of an inflammatory breast cancer: a case report and review of the literature / Ballesio, Laura; D'Ambrosio, Ilaria; Ravazzolo, Nelia; Angeletti, Marco; DI PASTENA, Francesca; Tardioli, Stefano; Lodise, Pietro; Marini, Mario. - In: LA CLINICA TERAPEUTICA. - ISSN 0009-9074. - STAMPA. - 162:4(2011), pp. 351-354.

Skin thickening as unique pathologic sign of an inflammatory breast cancer: a case report and review of the literature.

BALLESIO, Laura;D'AMBROSIO, ILARIA;RAVAZZOLO, NELIA;ANGELETTI, MARCO;DI PASTENA, FRANCESCA;TARDIOLI, STEFANO;LODISE, PIETRO;MARINI, Mario
2011

Abstract

We report the case of a 42-year-old woman with inflammatory cancer of the right breast treated with neoadjuvant chemotherapy, surgery, additional chemotherapy, and consolidative radiotherapy (RT), that has metastatized to the chest wall and presented a resumption of disease on the contralateral breast. Magnetic Resonance (MR), performed after the second phase's fourth round of additional chemotherapy, showed a modest reduction of scar metastases on the right and a contralateral anomalous skin thickening with high signal intensity in T2 weighted images (WI) with multiple mass-like enhancements located in a wide area of the central region at the union of higher quadrants. These findings were suggestive for resumption of contralateral disease; the biopsy confirmed an inflammatory breast cancer (IBC) infiltrating lobular type with high mitotic rate. A retrospective evaluation of the previous MR exam, performed 5 months before, was conducted: on the left side only a modest skin thickening was found as an early sign. A careful review of the literature has confirmed that skin thickening, increased density and clinical signs of inflammation are the most common findings in inflammatory cancer. We report the case of a patient affected by IBC whose unique early sign of resumption on the contralateral breast was skin thickening.
2011
breast cancer; breast mri; inflammatory breast cancer
01 Pubblicazione su rivista::01a Articolo in rivista
Skin thickening as unique pathologic sign of an inflammatory breast cancer: a case report and review of the literature / Ballesio, Laura; D'Ambrosio, Ilaria; Ravazzolo, Nelia; Angeletti, Marco; DI PASTENA, Francesca; Tardioli, Stefano; Lodise, Pietro; Marini, Mario. - In: LA CLINICA TERAPEUTICA. - ISSN 0009-9074. - STAMPA. - 162:4(2011), pp. 351-354.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/422228
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