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EnglishOne hundred and eight unselected patients with acute nonlymphocytic leukemia (ANLL) were treated with a combination of daunorubicin, cytosine arabinoside and 6-thioguanine (DAT). The complete remission rate was 54.6% and was achieved after an average of 2.3 courses of therapy. Among the initial variables, erythroleukemia morphology was the single most important prognostic factor, being associated with a poorer response rate (14.2%). Median remission duration was 48 weeks and median survival was 75 weeks; the estimated proportions of responders alive at 1 and 2 y from diagnosis were 71 and 35% respectively. Severe myelosuppression was the most common toxic effect observed during induction. DAT combination is an effective remission induction regimen for ANLL patients of all age groups. © 1979.
Daunorubicin, cytosine arabinoside and 6-thioguanine (DAT) combination chemotherapy for the treatment of acute non-lymphocytic leukemia / Sergio, Amadori; Giuseppe, Papa; Giovanna, Meloni; Leonardo, Pacilli; Mandelli, Franco. - In: LEUKEMIA RESEARCH. - ISSN 0145-2126. - 3:3(1979), pp. 147-152. [10.1016/0145-2126(79)90012-2]
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| Titolo: | Daunorubicin, cytosine arabinoside and 6-thioguanine (DAT) combination chemotherapy for the treatment of acute non-lymphocytic leukemia | |
| Autori: | ||
| Data di pubblicazione: | 1979 | |
| Rivista: | ||
| Citazione: | Daunorubicin, cytosine arabinoside and 6-thioguanine (DAT) combination chemotherapy for the treatment of acute non-lymphocytic leukemia / Sergio, Amadori; Giuseppe, Papa; Giovanna, Meloni; Leonardo, Pacilli; Mandelli, Franco. - In: LEUKEMIA RESEARCH. - ISSN 0145-2126. - 3:3(1979), pp. 147-152. [10.1016/0145-2126(79)90012-2] | |
| Handle: | http://hdl.handle.net/11573/421503 | |
| Appartiene alla tipologia: | 01a Articolo in rivista |
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