The biogenic quaternary amines leptodactiline, candicine and murexine, when injected into the third ventricle of rat brain, produced desynchronizing pattern followed by the appearance of epileptiform activity in both cortical and subcortical structures (caudate nucleus and reticular formation). Application of atropine abolished the induced epileptic activity. The injection of leptodactiline and candicine but not that of murexine into the caudate nucleus caused activity changes which first appeared there. The present results, confirming previous data observed in molluscan nerve cells, suggest that the trymethylammonium group present in all the tested molecules plays an important role in inducing the observed patterns. © 1981 The Italian Pharmacological Society.
Epileptic patterns induced by some biogenic amines injected in the rat brain / P. F. A., Barra; Berardelli, Alfredo; A., Brancati; C., Pacitti. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 13:7(1981), pp. 657-663.