Background: Current guidelines recommend non-invasive testing and treatment of young dyspeptic patients without alarm symptoms. Aim: To evaluate the accuracy of a new rapid immunochromatographic stool test to diagnose Helicobacter pylori infection before and after treatment compared with a gold standard. Methods: Prospective, single-blind study, performed in a tertiary care hospital. A total of 303 consecutive dyspeptic patients underwent endoscopy with multiple biopsies. Infected patients were offered a treatment and invited to come back 4-6 weeks after the end of therapy to repeat the endoscopy. Patients were also asked to provide a stool sample before and after therapy. Results: About 149 patients were H. pylori infected. The sensitivity and specificity before treatment were 91.3 and 93.5%; after treatment 92 and 100%. The likelihood ratios were robust enough to produce significant changes from pretest to post-test probability both in pretreatment (LR+ = 14, LR- = 0.093) and post-treatment (LR+ = 19.6, LR- = 0.095). Conclusions: The novel immunochromatographic stool test is fast, easy to perform and provides good differentiation between positive and negative results. It might become a rapid near patients test easily performed in the doctor office.

A rapid immunochromatographic assay for Helicobacter pylori in stool before and after treatment / L., Gatta; F., Perna; C., Ricci; Osborn, John Frederick; A., Tampieri; V., Bernabucci; M., Miglioli; D., Vaira. - In: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. - ISSN 0269-2813. - 20:4(2004), pp. 469-474. [10.1111/j.1365-2036.2004.02094.x]

A rapid immunochromatographic assay for Helicobacter pylori in stool before and after treatment

OSBORN, John Frederick;
2004

Abstract

Background: Current guidelines recommend non-invasive testing and treatment of young dyspeptic patients without alarm symptoms. Aim: To evaluate the accuracy of a new rapid immunochromatographic stool test to diagnose Helicobacter pylori infection before and after treatment compared with a gold standard. Methods: Prospective, single-blind study, performed in a tertiary care hospital. A total of 303 consecutive dyspeptic patients underwent endoscopy with multiple biopsies. Infected patients were offered a treatment and invited to come back 4-6 weeks after the end of therapy to repeat the endoscopy. Patients were also asked to provide a stool sample before and after therapy. Results: About 149 patients were H. pylori infected. The sensitivity and specificity before treatment were 91.3 and 93.5%; after treatment 92 and 100%. The likelihood ratios were robust enough to produce significant changes from pretest to post-test probability both in pretreatment (LR+ = 14, LR- = 0.093) and post-treatment (LR+ = 19.6, LR- = 0.095). Conclusions: The novel immunochromatographic stool test is fast, easy to perform and provides good differentiation between positive and negative results. It might become a rapid near patients test easily performed in the doctor office.
2004
01 Pubblicazione su rivista::01a Articolo in rivista
A rapid immunochromatographic assay for Helicobacter pylori in stool before and after treatment / L., Gatta; F., Perna; C., Ricci; Osborn, John Frederick; A., Tampieri; V., Bernabucci; M., Miglioli; D., Vaira. - In: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. - ISSN 0269-2813. - 20:4(2004), pp. 469-474. [10.1111/j.1365-2036.2004.02094.x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/421
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