Fibrillary glomerulonephritis (FibGN) is a rare cause of progressive renal dysfunction, often leading to dialysis within a few years. A 60-year-old woman presented with a 2 month history of right-sided retro-orbital pain and recent diplopia. Laboratory testing revealed an altered renal function with increased serum creatinine and mild proteinuria. MRI of the brain revealed the presence of a soft tissue mass on the right cavernous sinus compatible with the diagnosis of Tolosa-Hunt syndrome (THS). Renal biopsy showed a pattern compatible with fibrillary glomerulonephritis. For this reason steroid therapy was initiated at a dose of 1 mg/kg/day and adjusted according to the clinical course. Neurological symptoms regressed shortly after the beginning of therapy and renal function and proteinuria remained stable for the 3 years following the withdrawal of steroid therapy. Percutaneous renal biopsy was again performed and confirmed the previous diagnosis of FibGN in association with other glomerular-lesion-like mesangial widening, thickening of capillary walls and severe arterio-arteriolosclerosis. This case report describes what is believed to first report of the association of FibGN and THS, which both responded to steroid therapy.

A simultaneous occurrence of Tolosa-Hunt syndrome and fibrillary glomerulonephritis: a case report / Gigante, Antonietta; Giannakakis, Konstantinos; Visentini, Marcella; Fiorilli, Massimo; Barbano, Biagio; R., Renzulli; F., Borghesi; Cianci, Rosario. - In: JOURNAL OF CLINICAL PATHOLOGY. - ISSN 0021-9746. - 62:2(2009), pp. 190-191. [10.1136/jcp.2008.061648]

A simultaneous occurrence of Tolosa-Hunt syndrome and fibrillary glomerulonephritis: a case report

GIGANTE, ANTONIETTA;GIANNAKAKIS, Konstantinos;VISENTINI, MARCELLA;FIORILLI, Massimo;BARBANO, BIAGIO;CIANCI, ROSARIO
2009

Abstract

Fibrillary glomerulonephritis (FibGN) is a rare cause of progressive renal dysfunction, often leading to dialysis within a few years. A 60-year-old woman presented with a 2 month history of right-sided retro-orbital pain and recent diplopia. Laboratory testing revealed an altered renal function with increased serum creatinine and mild proteinuria. MRI of the brain revealed the presence of a soft tissue mass on the right cavernous sinus compatible with the diagnosis of Tolosa-Hunt syndrome (THS). Renal biopsy showed a pattern compatible with fibrillary glomerulonephritis. For this reason steroid therapy was initiated at a dose of 1 mg/kg/day and adjusted according to the clinical course. Neurological symptoms regressed shortly after the beginning of therapy and renal function and proteinuria remained stable for the 3 years following the withdrawal of steroid therapy. Percutaneous renal biopsy was again performed and confirmed the previous diagnosis of FibGN in association with other glomerular-lesion-like mesangial widening, thickening of capillary walls and severe arterio-arteriolosclerosis. This case report describes what is believed to first report of the association of FibGN and THS, which both responded to steroid therapy.
2009
01 Pubblicazione su rivista::01a Articolo in rivista
A simultaneous occurrence of Tolosa-Hunt syndrome and fibrillary glomerulonephritis: a case report / Gigante, Antonietta; Giannakakis, Konstantinos; Visentini, Marcella; Fiorilli, Massimo; Barbano, Biagio; R., Renzulli; F., Borghesi; Cianci, Rosario. - In: JOURNAL OF CLINICAL PATHOLOGY. - ISSN 0021-9746. - 62:2(2009), pp. 190-191. [10.1136/jcp.2008.061648]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/419089
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