We recently observed (February 1999) a 68-year old patient with endocarditis on a prosthetic biologic valve caused by a vancomycin-resistant Enterococcus faecalis. Broth dilution tests showed susceptibility to ampicillin (MIC = 0.5 mug/ml), no high resistance to aminoglycosides (MIC for gentamicin <500 <mu>g/ml) and resistance to vancomycin (MIC >256 mug/ml) and teicoplanin (MIC>16 mug/ml). A PCR assay detected vanA gene in this strain. A transthoracic echocardiogram did not show valvular vegetations. A possible endocarditis was diagnosed and the patient received ampicillin for 8 weeks and gentamicin for 6 weeks. The patient remained afebrile after a 4-month follow-up when he underwent surgical replacement of the dysfunctional bioprosthetic valve. Mitral valve was sterile on culture, but histology confirmed the diagnosis of previous endocarditis, This is the third case of endocarditis caused by vancomycin-resistant E. faecalis reported to date.

Prosthetic biologic valve endocarditis caused by a vancomycin-resistant (vanA) Enterococcus faecalis: Case report / P., Carfagna; A., Tarasi; M., Cassone; M. F., Del Grosso; G., Bianco; Venditti, Mario. - In: JOURNAL OF CHEMOTHERAPY. - ISSN 1120-009X. - STAMPA. - 12:5(2000), pp. 416-420.

Prosthetic biologic valve endocarditis caused by a vancomycin-resistant (vanA) Enterococcus faecalis: Case report

VENDITTI, Mario
2000

Abstract

We recently observed (February 1999) a 68-year old patient with endocarditis on a prosthetic biologic valve caused by a vancomycin-resistant Enterococcus faecalis. Broth dilution tests showed susceptibility to ampicillin (MIC = 0.5 mug/ml), no high resistance to aminoglycosides (MIC for gentamicin <500 g/ml) and resistance to vancomycin (MIC >256 mug/ml) and teicoplanin (MIC>16 mug/ml). A PCR assay detected vanA gene in this strain. A transthoracic echocardiogram did not show valvular vegetations. A possible endocarditis was diagnosed and the patient received ampicillin for 8 weeks and gentamicin for 6 weeks. The patient remained afebrile after a 4-month follow-up when he underwent surgical replacement of the dysfunctional bioprosthetic valve. Mitral valve was sterile on culture, but histology confirmed the diagnosis of previous endocarditis, This is the third case of endocarditis caused by vancomycin-resistant E. faecalis reported to date.
2000
endocarditis; enterococcus faecalis; enterococcus faecium; glycopeptide resistance; vancomycin resistance
01 Pubblicazione su rivista::01a Articolo in rivista
Prosthetic biologic valve endocarditis caused by a vancomycin-resistant (vanA) Enterococcus faecalis: Case report / P., Carfagna; A., Tarasi; M., Cassone; M. F., Del Grosso; G., Bianco; Venditti, Mario. - In: JOURNAL OF CHEMOTHERAPY. - ISSN 1120-009X. - STAMPA. - 12:5(2000), pp. 416-420.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/418968
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 7
social impact