Seven cases of enterococcal endocarditis treated with teicoplanin (7-10 mg/kg/day for 28-105 days) alone (one case) or in combination with aminoglycosides (six cases) were reviewed. All patients were cured. Serum bactericidal activity titres after intravenous gentamicin (5 mg/kg every 24 h) and teicoplanin (10 mg/kg every 24 h) were measured on day 7 of treatment in four patients against five enterococcal isolates: mean titres were 1:54 (range 1:16-64) and 1:22 (1:8-32) at 0.5 and 24 h post-infusion, respectively. Time-kill studies showed synergy between teicoplanin and gentamicin against three isolates. We conclude that single daily-dose teicoplanin/gentamicin combined therapy may represent a rational alternative to standard penicillin/gentamicin therapy and a useful regimen for home treatment of selected cases of enterococcal endocarditis.

Teicoplanin in the treatment of enterococcal endocarditis: clinical and microbiological study / Venditti, Mario; A., Tarasi; A., Capone; M., Galie; F., Menichetti; P., Martino; P., Serra. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - STAMPA. - 40:3(1997), pp. 449-452. [10.1093/jac/40.3.449]

Teicoplanin in the treatment of enterococcal endocarditis: clinical and microbiological study

VENDITTI, Mario;
1997

Abstract

Seven cases of enterococcal endocarditis treated with teicoplanin (7-10 mg/kg/day for 28-105 days) alone (one case) or in combination with aminoglycosides (six cases) were reviewed. All patients were cured. Serum bactericidal activity titres after intravenous gentamicin (5 mg/kg every 24 h) and teicoplanin (10 mg/kg every 24 h) were measured on day 7 of treatment in four patients against five enterococcal isolates: mean titres were 1:54 (range 1:16-64) and 1:22 (1:8-32) at 0.5 and 24 h post-infusion, respectively. Time-kill studies showed synergy between teicoplanin and gentamicin against three isolates. We conclude that single daily-dose teicoplanin/gentamicin combined therapy may represent a rational alternative to standard penicillin/gentamicin therapy and a useful regimen for home treatment of selected cases of enterococcal endocarditis.
1997
01 Pubblicazione su rivista::01a Articolo in rivista
Teicoplanin in the treatment of enterococcal endocarditis: clinical and microbiological study / Venditti, Mario; A., Tarasi; A., Capone; M., Galie; F., Menichetti; P., Martino; P., Serra. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - STAMPA. - 40:3(1997), pp. 449-452. [10.1093/jac/40.3.449]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/418895
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