Background: A condition of maternal thrombophilia, either inherited or acquired, can compromise the success of implantation and foetal survival. Methods: Malfunctions in protein C pathway were evaluated using a novel assay [HemosIL ThromboPath (ThP)] in a case-control study of 172 women with a history of recurrent miscarriage or infertility and 86 age-matched unrelated fertile women. Results: Thrombophilia was ascertained in 13% of the cases. ThP values were lower in women either with or without thrombophilia compared to controls (both p<0.0001). Abnormal ThP values (below the mean minus 1SD of controls) were found in 62% of cases compared to 12% of controls (p<0.0001). Nonthrombophilic women who achieved spontaneous pregnancy had higher ThP values compared to those who did not (p<0.05). Elevated ThP values were an independent predictor for pregnancy (p<0.01) in women without thrombophilia. A decrease of ThP values was observed during pregnancy progression, which correlated with that of protein S (p<0.05). Miscarriage or major complications occurred in women in whom ThP percent change was approximately 2-fold higher than that observed in women who achieved successful pregnancy (p<0.05). Conclusions: ThP might represent an efficient assay for screening women with pregnancy complications and might provide prognostic information during pregnancy progression. (C) 2009 Elsevier B.V. All rights reserved.

Predictive value of thrombopath determination in women with infertility and pregnancy complications / Ferroni, Patrizia; Francesca La, Farina; Raffaele, Palmirotta; Francesca, Martini; Raparelli, Valeria; Nigro, Carmen; Riondino, Silvia; Maria Rita, Rampini; Basili, Stefania; Fiorella, Guadagni. - In: CLINICA CHIMICA ACTA. - ISSN 0009-8981. - STAMPA. - 411:1-2(2010), pp. 37-42. [10.1016/j.cca.2009.09.035]

Predictive value of thrombopath determination in women with infertility and pregnancy complications

FERRONI, Patrizia;RAPARELLI, Valeria;NIGRO, CARMEN;RIONDINO, Silvia;BASILI, Stefania;
2010

Abstract

Background: A condition of maternal thrombophilia, either inherited or acquired, can compromise the success of implantation and foetal survival. Methods: Malfunctions in protein C pathway were evaluated using a novel assay [HemosIL ThromboPath (ThP)] in a case-control study of 172 women with a history of recurrent miscarriage or infertility and 86 age-matched unrelated fertile women. Results: Thrombophilia was ascertained in 13% of the cases. ThP values were lower in women either with or without thrombophilia compared to controls (both p<0.0001). Abnormal ThP values (below the mean minus 1SD of controls) were found in 62% of cases compared to 12% of controls (p<0.0001). Nonthrombophilic women who achieved spontaneous pregnancy had higher ThP values compared to those who did not (p<0.05). Elevated ThP values were an independent predictor for pregnancy (p<0.01) in women without thrombophilia. A decrease of ThP values was observed during pregnancy progression, which correlated with that of protein S (p<0.05). Miscarriage or major complications occurred in women in whom ThP percent change was approximately 2-fold higher than that observed in women who achieved successful pregnancy (p<0.05). Conclusions: ThP might represent an efficient assay for screening women with pregnancy complications and might provide prognostic information during pregnancy progression. (C) 2009 Elsevier B.V. All rights reserved.
2010
infertility; miscarriage; pregnancy; thrombophilia; thrombosis; women
01 Pubblicazione su rivista::01a Articolo in rivista
Predictive value of thrombopath determination in women with infertility and pregnancy complications / Ferroni, Patrizia; Francesca La, Farina; Raffaele, Palmirotta; Francesca, Martini; Raparelli, Valeria; Nigro, Carmen; Riondino, Silvia; Maria Rita, Rampini; Basili, Stefania; Fiorella, Guadagni. - In: CLINICA CHIMICA ACTA. - ISSN 0009-8981. - STAMPA. - 411:1-2(2010), pp. 37-42. [10.1016/j.cca.2009.09.035]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/41887
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